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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of…
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TLDR: This case study reports the highest recorded nonfatal clozapine overdose (10,000 mg) in an elderly patient, causing significant fluctuations in blood concentration levels following treatment. Highlights: A 71-year-old female ingested 10,000 mg of clozapi…
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Schizophrenia is a severe mental illness characterized by hallucinations, delusions, disorganized thinking and behavior. While antipsychotic medications can help manage symptoms, their long-term effects on brain structure are not fully understood. A new study…
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Antipsychotic medications are commonly used to treat psychotic disorders like schizophrenia and bipolar disorder. However, these drugs often cause side effects like elevated prolactin levels, which can negatively impact long-term health. A new study analyzed m…
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A new study published in Pharmazie takes a close look at adverse event reports related to drug-induced weight gain submitted to the FDA over the past 10 years. The retrospective analysis provides insight into the drugs most commonly associated with weight gain…
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