TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatment: Late middle-aged 18-month-old male and female C57BL/6J mice received two intranasal doses of hiPSC-NSC-EVs before assessment in old …
TL;DR: A 2026 study in iScience found that 1 hour of small-space confinement suppressed male courtship in Drosophila, and dopamine signaling into the mushroom body was needed to keep that suppression going after the stress ended. Key Findings 1-hour stress model: Male flies confined in a 3 mm by 2 mm small-space chamber showed reduced …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more frequent. Key Findings 25 RCTs: The review included 25 double-blind randomized controlled trials with 6,812 randomized participants. Subjective sleep …
TL;DR: A 2026 preprint in medRxiv surveyed people with multiple system atrophy and found that neurogenic orthostatic hypotension was often underdiagnosed, rarely fully controlled, and strongly tied to daily function and caregiver burden. Key Findings 259 MSA respondents: The survey analyzed 259 people with self-reported multiple system atrophy, with mean age 64.38 years and 44% …
TL;DR: A 2026 review in Neuropsychiatric Disease and Treatment argues that miR-425-3p is a candidate depression biomarker because it connects stress biology, MAPK/Wnt signaling, inflammation, and antidepressant response evidence. Key Findings 280 million MDD burden: The review opens from the scale of major depressive disorder, which affects more than 280 million people worldwide. About 20-fold …
TL;DR: A 2026 study in Interactive Journal of Medical Research used structured hospital records plus natural language processing of clinical notes to profile major depressive disorder in Belgium, finding that 46% of 1,147 adults met a real-world treatment-resistant depression definition. Key Findings Belgian EHR cohort: The retrospective study drew from 1,147 adults with major depressive …
TL;DR: A 2026 study in Nature Communications used cryo-electron microscopy and patch-clamp recordings to show how partially occupied GluK2/GluK5 kainate receptors can activate without entering the fast desensitized state that normally shuts glutamate receptors down. Key Findings Fast glutamate shutdown: Glutamate triggered receptor activation in less than 1 ms, followed by complete desensitization in about …
TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals. Key Findings Four-phase adaptation: The WHO iSupport dementia program was translated into Bahasa Malaysia, culturally adapted, and rebuilt as multimedia e-learning. 23 …
TL;DR: A 2025 mouse study in eNeuro reported that inhaled cannabidiol reduced IDO and cGAS pathway activity and lowered pro-inflammatory cytokines in male 5XFAD Alzheimer’s model mice. Key Findings 5XFAD model: The study used male 5XFAD transgenic mice, a common amyloid-heavy Alzheimer’s disease model. Inhaled CBD: Cannabidiol was administered by inhalation rather than by oral …
TL;DR: A 2026 study in iScience found that migraine patients with patent foramen ovale had altered plasma metabolic profiles, with lower indoleacrylic acid and an IA-plus-hs-CRP marker pair showing exploratory discrimination in a validation cohort. Key Findings 30 discovery patients: Untargeted metabolomics compared 30 migraine patients with patent foramen ovale against 17 matched controls. 4,858 …
