GPR30 Estrogen Receptor May Link Hormone Fluctuations to Migraine Pathophysiology
TL;DR: A 2026 review in Journal of Pain Research argued that G protein-coupled receptor 30 (GPR30/GPER), a membrane estrogen receptor, could help connect estrogen fluctuations with migraine biology. Key Findings Female-predominant migraine: The review notes a female-to-male migraine prevalence ratio of about 2:1 to 3:1. Menstrual migraine link: About 50% to 60% of female migraineurs …
