Gene-Silencing Molecule Lowered Alpha-Synuclein and Protected Dopamine Cells in Parkinson’s Mice

Gene-Silencing Molecule Lowered Alpha-Synuclein and Protected Dopamine Cells in Parkinson's Mice

TL;DR: In mice, a new type of gene-silencing molecule lowered levels of alpha-synuclein, the protein that clumps in Parkinson’s. Mice given it kept more dopamine-making brain cells and did better on grip and balance tests than untreated mice with the same disease model. Key Findings Two silencing molecules tested: Both cut alpha-synuclein in the brain …

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Picturing a Positive Future May Help People With Low Mood Feel More in Control of Their Goals

Picturing a Positive Future May Help People With Low Mood Feel More in Control of Their Goals

TL;DR: In a lab study of 187 UK students, a few minutes spent vividly imagining good future events made those with more low-mood symptoms feel more in control of their goals. It did not make anyone feel their goals were more likely or more important. Key Findings 187 students, 4 groups: Imagined their own goal …

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Exercise and Social Support Linked to Better Thinking in Mild Cognitive Impairment

Exercise and Social Support Linked to Better Thinking in Mild Cognitive Impairment

TL;DR: Among 112 older adults in Spain with mild cognitive impairment, those who reported more physical activity and felt more supported by family and friends scored better on several thinking tests. The study took one snapshot, so it cannot show that activity or support protects thinking. Key Findings 112 adults, average age 71: All had …

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Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

TL;DR: In a small Spanish pilot, adults at high risk of depression got a personalized prevention plan from their family doctor plus an app. After 3 months their predicted depression risk and anxiety scores fell, but depression symptoms did not, most people barely used the app, and there was no comparison group. Key Findings 56 …

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Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

TL;DR: Pooling 59 trials, all from China, researchers found that adding acupuncture or electroacupuncture to standard rehab after a stroke was linked to better leg movement scores for people with foot drop. But the studies varied widely and many had quality problems, so the size of the benefit is uncertain. Key Findings 59 trials, 4,596 …

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Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

TL;DR: In 10 young adults with a neck-level spinal cord injury, standing upright in a frame made blood pressure drop. Wearing compression stockings and a belly binder kept blood pressure from falling, and the five people who felt faint said they felt better. Key Findings Standing lowered blood pressure: Pressure and pulse pressure fell significantly …

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Brief Force Bursts in the Head During Sleep Were Less Frequent in People With Brain Disease, Preprint Finds

Brief Force Bursts in the Head During Sleep Were Less Frequent in People With Brain Disease, Preprint Finds

TL;DR: A headband sensor picked up brief bursts of force inside the head during sleep in all 45 people tested. People with neurodegenerative diseases had fewer bursts per minute than healthy volunteers, in an early, not yet peer-reviewed study. Key Findings A new sleep signal: 1- to 2-second “sleep bursts” showed up in every one …

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Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

TL;DR: At a leading London children’s hospital, 77 children with PRES, a sudden brain-swelling syndrome, were reviewed over 20 years. Nearly 4 in 5 first showed up with seizures, almost all had another serious illness, and about a third of those given seizure medicine still needed it after 6 months. Key Findings Seizures came first: …

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