NDST3 Suppression Restored Lysosomal Acidification in Alzheimer’s Models
TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Findings Lysosomal pH shifted back: APP695Swe-overexpressing HT22 cells had lysosomal pH near 5.6, while Ndst3 knockdown lowered it to less than …
