TL;DR: A 2026 review in Current Opinion in Psychiatry found that earlier clozapine use in schizophrenia, especially after early nonresponse or relapse, was linked to better relapse prevention and stronger response rates than repeated nonclozapine antipsychotic trials. Key Findings Relapse prevention improved: Switching to clozapine after first relapse was associated with a 34% lower subsequent …
TL;DR: A 2026 mouse study in Neurochemical Research found that 28 days of unpredictable chronic mild stress increased dopamine D1 receptor binding across the striatum and raised dopamine D2 receptor binding only in selected regions, regardless of fatty acid-binding protein 7 gene deletion. Key Findings Adult male mice were exposed to 28 days of unpredictable …
TL;DR: A 2026 Phase I study in CNS Drugs found that a 400 mg powdered cannabidiol (CBD) formulation reached peak blood levels faster than oil-based Epidyolex, especially after a high-fat meal, while both products were generally well tolerated in healthy adults. Key Findings Four-way crossover trial: Researchers gave 32 healthy adults single 400 mg doses …
TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knockout mice. Key Findings CB1R accumulated up to 10-fold: Blocking autophagic flux with Bafilomycin A1 in …
TL;DR: A 2026 study in Nature Communications found that different brain-connectivity measures predicted different parts of associative learning: functional connectivity predicted acquisition, structural connectivity predicted extinction learning, and effective connectivity was most informative for renewal. Key Findings 509 resting-state fMRI scans: Researchers analyzed resting-state functional MRI data from 509 participants across six learning studies. 463 …
TL;DR: A 2026 Research Square preprint linked DNA methylation (DNAm), an epigenetic mark measured in cord blood at birth, with default mode network-limbic brain development and age-13 anxiety symptoms in boys. Key Findings Birth-to-teen pathway tested: Researchers analyzed 97 children from the GUSTO birth cohort who had cord-blood DNAm, repeated resting-state functional MRI (fMRI) scans, …
TL;DR: A 2026 preprint in medRxiv found that 26 autistic children and 25 typically developing peers performed similarly on iPad-based navigation tasks, but the autistic group rated its own sense of direction lower. Key Findings Objective navigation performance did not differ between autistic and typically developing children across path integration, egocentric pointing, mapping, or perspective …
TL;DR: A 2026 case study in Neurological Sciences described 2 Tourette syndrome patients who developed oculogyric crisis, a sustained upward eye-rolling dystonia, after aripiprazole was increased to 20-30 mg/day, with both cases resolving after dose reduction. Key Findings 2 Tourette cases: The report described 2 female patients, ages 16 and 22, treated with aripiprazole for …
TL;DR: A 2026 medRxiv preprint reported that Hwa-free, a 4-week acceptance and commitment therapy app for Hwa-byung, was used on an average of 19.9 of 28 days and was followed by lower Hwa-byung symptoms, depression scores, and state anger in a small single-arm pilot trial. Key Findings 28-person analysis: Researchers enrolled 30 adults with Hwa-byung, …
TL;DR: A 2026 cross-sectional study in Metabolic Brain Disease linked adult attention-deficit/hyperactivity disorder (ADHD) with lower serum SIRT-1, Nrf-2, and HO-1, three redox-regulation markers tied to antioxidant defense. Key Findings 120 adults studied: The analysis compared 60 adults with ADHD against 60 age- and sex-matched healthy controls. SIRT-1 was lower: Mean serum SIRT-1 was 9.36 …
