TL;DR: A 2026 systematic review and meta-analysis in Brain, Behavior, & Immunity – Health found that adding celecoxib to antidepressants was linked to lower depressive symptom scores in 7 small trials, but the efficacy evidence was rated very low certainty. Key Findings 7 randomized trials: The meta-analysis included 365 adults with major depressive disorder, with …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Alzheimer’s Disease found that choroid plexus volume, an MRI-visible structure involved in cerebrospinal-fluid regulation and immune signaling, was larger in Alzheimer’s disease than in healthy controls. Key Findings Sixteen studies: The review included 16 MRI-based studies covering 2,004 Alzheimer’s disease patients and 883 healthy controls. …
TL;DR: A 2026 study in Nature Communications found that neuropsychiatric disorder risk did not map onto cognition as one general trait. Schizophrenia, bipolar disorder, ADHD, autism, and Alzheimer’s disease showed different genetic links with reaction time, fluid reasoning, crystallized knowledge, and noncognitive educational skills. Key Findings 439,000-person GWAS scale: The crystallized-knowledge genome-wide association study had …
TL;DR: A 2026 secondary analysis in Addiction found that adults switched to very-low-nicotine cigarettes often used alternative nicotine products and maintained much higher nicotine intake than cigarette-only users. Key Findings 438 smokers: The parent randomized clinical trial enrolled adults who smoked 5 to 40 cigarettes per day. 0.4 mg/g cigarettes: The very-low-nicotine-content group received Spectrum …
TL;DR: A 2026 systematic review in Future Science OA found early medication evidence for online behavioral addictions, but the 20 included studies were mostly small, male-heavy, and short-term. Key Findings Medication evidence stayed early: The review found small, mixed pharmacotherapy signals across 20 online behavioral addiction studies. Clinical groups stayed small: The 1,016 total participants …
TL;DR: A 2026 real-world study in Journal of Clinical Sleep Medicine found that glucagon-like peptide-1 receptor agonist use was associated with lower 3-year cardiovascular-event risk in adults with obesity and obstructive sleep apnea. Key Findings 18,523 matched pairs: Propensity matching compared GLP-1 receptor agonist users with similar non-users who had obesity and obstructive sleep apnea. …
TL;DR: A 2026 crossover study in Clinical Physiology and Functional Imaging found that adding electrical muscle stimulation to low-intensity resistance exercise improved inhibitory control in young men, while stimulation alone showed a delayed 15-minute benefit. Key Findings 17 young men: Participants completed low-intensity resistance exercise, electrical muscle stimulation alone, and combined low-intensity exercise plus stimulation …
TL;DR: A 2026 pilot randomized trial in Nursing in Critical Care found that an 8-week home-based program combining exercise with computerized cognitive training was feasible in 36 ICU survivors and produced larger reductions in patient-reported post-intensive care syndrome severity than attention control, while exploratory cognitive and quality-of-life effect sizes generally favored the combined program over …
TL;DR: A 2026 review in International Journal of Nanomedicine argued that depression nanomedicine should move beyond blood-brain-barrier delivery alone and be judged by target engagement, neuroimmune-barrier-plasticity effects, safety, manufacturability, and patient stratification. Key Findings Mechanism-centered review: The paper organized depression nanomedicine around neuroinflammation, blood-brain-barrier dysfunction, oxidative stress, and impaired neuroplasticity. 3 strategy groups: The review …
TL;DR: A 2026 study in European Journal of Nuclear Medicine and Molecular Imaging found that semiquantitative [123I]FP-CIT SPECT metrics, especially caudate-to-putamen and sensorimotor-to-limbic ratios, helped distinguish Parkinson’s disease from atypical parkinsonian syndromes, while a random forest classifier remained more useful as decision support than as a standalone diagnosis. Key Findings 706-patient cohort: The study included …
