Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

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Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

TL;DR: A 2026 mouse study in Psychopharmacology found that repeated dexamethasone, a synthetic glucocorticoid steroid, disrupted light-phase sleep and increased orexin-neuron activity, a wake-promoting hypothalamic signal, during sleep-to-wake transitions. Key Findings 5-day steroid model: Male C57BL/6J mice received dexamethasone at 30 mg/kg for 5 days before 24-hour sleep recording. Light-phase sleep was disrupted: Dexamethasone increased …

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CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

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CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

TL;DR: A 2026 systematic review in Journal of Clinical Sleep Medicine found that cognitive behavioral therapy for insomnia (CBT-I), a structured behavioral sleep treatment, plus sleep medication improved chronic insomnia more than medication alone, but adding medication to CBT-I did not improve the critical insomnia outcomes. Key Findings 15 analyzable articles: Researchers screened 1,179 articles, …

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BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

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BIOMEDE Trial Found No Survival Gain From Targeted Drugs in DIPG

TL;DR: A 2026 randomized phase 2 trial in Nature Medicine found that three targeted drugs added to radiotherapy did not improve overall survival for children with diffuse intrinsic pontine glioma (DIPG), a lethal brainstem tumor, although everolimus caused fewer treatment-stopping side effects. Key Findings 233 randomized patients: BIOMEDE assigned 36 children to erlotinib, 102 to …

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Olfactory MRI Radiomics Linked pTau217 to Alzheimer’s Cognition

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Olfactory MRI Radiomics Linked pTau217 to Alzheimer's Cognition

TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, with cognitive impairment across three cohorts. Key Findings Three Alzheimer’s cohorts were matched: Researchers matched 122 Alzheimer’s disease (AD) patients …

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Alzheimer’s AI Model Improved Disease Progression Prediction

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Alzheimer's AI Model Improved Disease Progression Prediction

TL;DR: A 2026 machine-learning study found that the final SNP-NF model in PLOS One reported mAUC 0.965, recall 0.929, and precision 0.929, while the study reported gains of about 3% in mAUC, 1% in precision, and 0.7% in recall versus their previous neural-process model. Key Findings SNP-NF performance was high: The final model reported mAUC …

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Social Media Abstinence Did Not Improve Mood or Life Satisfaction in 10-Study Meta-Analysis of 4,674 Adults

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Social Media Abstinence Did Not Improve Mood or Life Satisfaction in 10-Study Meta-Analysis of 4,674 Adults

TL;DR: A 2025 systematic review and meta-analysis in Scientific Reports pooled 10 social media abstinence experiments (N = 4,674 adults; abstinence 1–28 days) and found no significant effect on positive affect, negative affect, or life satisfaction. Key Findings Positive affect was unchanged: pooled Hedges’ g = 0.03 (95% CI [−0.11, 0.16], p = 0.69) across 9 studies and 14 …

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Oral Arginine Reduced Amyloid-Beta Pathology in Two Mouse Models of Alzheimer’s Disease

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Oral Arginine Reduced Amyloid-Beta Pathology in Two Mouse Models of Alzheimer's Disease

TL;DR: A 2025 study in Neurochemistry International from Kindai University showed that oral arginine, a naturally occurring amino acid, blocked the formation of toxic amyloid-beta aggregates in lab tests and reduced amyloid pathology in two well-established mouse models of Alzheimer’s disease — with the authors flagging that the research-grade doses and methods are not equivalent …

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Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

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Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

TL;DR: A 2026 randomized crossover trial in Cell Metabolism compared natural daylight against standard artificial office lighting in 13 older adults with well-controlled type 2 diabetes and found that natural-daylight days produced more time in a healthy blood-glucose range (about 51% vs 43%), smaller glucose swings, and a metabolic shift toward burning more fat and …

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Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

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Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

TL;DR: A 2026 study in the Journal of the American Heart Association followed 1,882 stroke-free women from the Framingham Heart Study for a median of 18 years and found that having three or more live births was associated with a reduced risk of clinical stroke and lower MRI markers of vascular brain injury — the …

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Lower-Body Cues Matched Whole-Body Accuracy in Female Body Size Judgments

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Lower-Body Cues Matched Whole-Body Accuracy in Female Body Size Judgments

TL;DR: A 2025 study in BMC Biology found that people judged female body size about as accurately from lower-body images as from whole-body images, but isolated thigh regions alone were not enough. Key Findings Two body-perception experiments: Researchers tested 99 participants in Experiment 1 and 116 participants in Experiment 2 using a bodyline task. Lower-body …

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