TL;DR: A 2026 review in Journal of Pain Research argued that G protein-coupled receptor 30 (GPR30/GPER), a membrane estrogen receptor, could help connect estrogen fluctuations with migraine biology. Key Findings Female-predominant migraine: The review notes a female-to-male migraine prevalence ratio of about 2:1 to 3:1. Menstrual migraine link: About 50% to 60% of female migraineurs …
TL;DR: A 2026 claims analysis in Exploratory Research in Clinical and Social Pharmacy found that FDA-declared first-generation antipsychotic shortages were followed by medication switching in 9.13% of included patients with psychotic spectrum disorders, with especially high switching after thiothixene, trifluoperazine, and molindone shortages. Key Findings The claims cohort was large: 95,968 patients had a psychotic …
TL;DR: A 2026 review in Psychonomic Bulletin & Review explained how the Diffusion Model for Conflict tasks (DMC) models attention and cognitive control in Simon, Eriksen flanker, and Stroop tasks. Key Findings 3 classic tasks: The review focused on Simon, Eriksen flanker, and Stroop conflict tasks. 2 evidence streams: DMC combines a linear controlled stream …
TL;DR: A 2026 study in Psychological Medicine found that transcranial direct current stimulation (tDCS), a weak electrical brain-stimulation method, affected empathy differently depending on whether researchers targeted the right temporoparietal junction or the left dorsolateral prefrontal cortex. Key Findings Two brain targets diverged: right temporoparietal junction (rTPJ) stimulation strengthened cognitive empathy, while left dorsolateral prefrontal …
TL;DR: A 2026 systematic review posted on medRxiv found that transcranial direct current stimulation (tDCS), a weak noninvasive brain-stimulation method, added to cognitive training produced a small short-term cognitive benefit across 27 trials, but the effect faded at follow-up and the evidence certainty was very low. Key Findings 27 controlled studies: The meta-analysis included 1,012 …
TL;DR: A 2026 study in The Pharmacogenomics Journal tested pharmacogenomic (PGx) depression care, meaning medication guidance based on drug-gene interactions; targeting Veterans already taking antidepressants with common PGx interactions raised the actionable-result rate to 30%, but immediate test-result access did not improve Patient Health Questionnaire-9 (PHQ-9) depression scores over 12 weeks. Key Findings 60 Veterans …
TL;DR: A 2026 preprint in medRxiv linked atypical absence seizures in SYNGAP1-related developmental and epileptic encephalopathy (SYNGAP1-DEE) to higher caregiver-reported autistic behavior scores, while caregiver-reported peak seizure frequency did not show the same association. Key Findings 337-person analytic cohort: Researchers analyzed 337 SYNGAP1 registry participants with complete epilepsy and behavior questionnaires. 259 epilepsy-positive participants: Epilepsy …
TL;DR: A 2026 study in BJPsych Bulletin used Freedom of Information requests and found that most English NHS trusts providing in-patient psychiatric care were unable to report basic data on which patients were parents of children under 18. Key Findings 50 trusts contacted: Researchers sent Freedom of Information requests to all English NHS trusts providing …
TL;DR: A 2026 iScience study recorded human substantia nigra neurons during Parkinson’s surgery and found that putative dopamine-neuron firing was higher after a prior reward, while the next response was modestly faster. Key Findings Direct human recordings: Researchers recorded 27 substantia nigra neurons across 13 sessions in 11 Parkinson’s disease patients undergoing deep-brain stimulation surgery. …
TL;DR: A 2026 study in Communications Biology found that restraint stress weakened medial prefrontal cortex (mPFC, a frontal brain region that helps organize social behavior) activity during social testing, while stress-activated amygdala and hypothalamic oxytocin inputs pushed the circuit toward inhibition. Key Findings Two-hour acute restraint preserved basic sociability but disrupted social novelty preference, suggesting …
