TL;DR: A 2026 review in Annals of Medicine argues that circadian rhythm disruption in major depressive disorder (MDD) reaches beyond poor sleep, linking clock-gene variation, sleep-wake timing, stress-hormone rhythms, melatonin signaling, and chronotherapy targets. Key Findings 264 million affected: The review frames MDD as a leading global disability cause affecting more than 264 million people. …
TL;DR: A 2026 systematic review and meta-analysis in Musculoskeletal Science and Practice found that people with carpal tunnel syndrome had higher blood markers tied to fibrosis and inflammation, along with lower vitamins and minerals, but the evidence was too heterogeneous for a diagnostic blood test. Key Findings 28-study review: Researchers analyzed 28 studies covering 2,840 …
TL;DR: A 2026 analysis in Brain, Behavior, & Immunity – Health of 827 middle-aged adults found that profiles combining intestinal-permeability biomarkers with age, cardiometabolic risk, or lifestyle factors were associated with smaller brain volumes and higher plasma neurofilament light in sex-specific patterns, with only the women’s profiles also associated with higher 4-year odds of neurological …
TL;DR: A 2026 systematic review and Bayesian meta-analysis in Journal of Medical Internet Research found that artificial intelligence models trained only on overnight pulse-oximetry oxygen-saturation data detected obstructive sleep apnea with 91.1% sensitivity and 88.4% specificity across 25 studies. Key Findings 25 studies and 23,171 participants were included: The review pooled adult studies that compared …
TL;DR: A 2026 Developmental Psychology randomized-trial follow-up found that children assigned to high-quality foster care after severe early deprivation had better adaptive functioning at age 18, especially in communication and socialization, than children who remained in care as usual. Key Findings Trial follow-up: The analysis used the Bucharest Early Intervention Project, a randomized trial comparing …
TL;DR: A 2026 laboratory study in ACS Omega reported that a laser-induced graphene sensor detected dopamine across a controlled range in artificial human tears, supporting a possible noninvasive biomarker-monitoring route that still needs real human tear testing. Key Findings Laser-induced graphene sensor: Researchers built a small electrochemical device on a plastic film converted into conductive …
TL;DR: A 2026 post-hoc reanalysis in Molecular Psychiatry found that women assigned davunetide in a prior 52-week progressive supranuclear palsy trial had more favorable scores on the 10-item PSP Rating Scale (PSPRS-10), daily-living measures, and several cognitive outcomes than women assigned placebo, but the subgroup result needs confirmation in a prospective trial designed to test …
TL;DR: A 2026 randomized active-control study in European Journal of Sport Science found that one 45-minute slackline practice session improved eyes-open slackline balance and increased resting-state electroencephalography (EEG) beta power in healthy slackline-naive adults, while eyes-closed balance and tibial somatosensory evoked potentials did not show the same selective change. Key Findings 35-person randomized sample: Researchers …
TL;DR: A 2025 medRxiv fMRI preprint linked higher apathy in both traumatic brain injury (TBI) and control groups to greater effort discounting, while TBI-related apathy was also associated with less exploratory decision-making and weaker neural encoding of differences between expected and received rewards. Key Findings 53-person fMRI sample: Researchers analyzed 34 people with chronic TBI …
TL;DR: A 2026 systematic review in Sports Medicine – Open found that esports gameplay can raise heart rate, stress physiology, and energy expenditure, but the overall metabolic demand generally stayed in the light-activity range. Key Findings 176 records screened: The review searched PubMed, Embase, SPORTDiscus, Web of Science, and Scopus before narrowing to 5 eligible …
