Pain Oversensitivity Is Common in Pancreatic Cancer, but Not Linked to Worse Daily Impact

Pain Oversensitivity Is Common in Pancreatic Cancer, but Not Linked to Worse Daily Impact

TL;DR: Among 121 people with painful pancreatic cancer, 44% had a heightened sensitivity to pain on standardized testing, much like people with long-term pancreatitis. But in the cancer group, that sensitivity was not consistently linked to worse pain, mood or quality of life. Key Findings 275 patients, 5 hospitals: 153 with chronic pancreatitis and 122 …

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Gene-Silencing Molecule Lowered Alpha-Synuclein and Protected Dopamine Cells in Parkinson’s Mice

Gene-Silencing Molecule Lowered Alpha-Synuclein and Protected Dopamine Cells in Parkinson's Mice

TL;DR: In mice, a new type of gene-silencing molecule lowered levels of alpha-synuclein, the protein that clumps in Parkinson’s. Mice given it kept more dopamine-making brain cells and did better on grip and balance tests than untreated mice with the same disease model. Key Findings Two silencing molecules tested: Both cut alpha-synuclein in the brain …

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Picturing a Positive Future May Help People With Low Mood Feel More in Control of Their Goals

Picturing a Positive Future May Help People With Low Mood Feel More in Control of Their Goals

TL;DR: In a lab study of 187 UK students, a few minutes spent vividly imagining good future events made those with more low-mood symptoms feel more in control of their goals. It did not make anyone feel their goals were more likely or more important. Key Findings 187 students, 4 groups: Imagined their own goal …

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Exercise and Social Support Linked to Better Thinking in Mild Cognitive Impairment

Exercise and Social Support Linked to Better Thinking in Mild Cognitive Impairment

TL;DR: Among 112 older adults in Spain with mild cognitive impairment, those who reported more physical activity and felt more supported by family and friends scored better on several thinking tests. The study took one snapshot, so it cannot show that activity or support protects thinking. Key Findings 112 adults, average age 71: All had …

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Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

TL;DR: In a small Spanish pilot, adults at high risk of depression got a personalized prevention plan from their family doctor plus an app. After 3 months their predicted depression risk and anxiety scores fell, but depression symptoms did not, most people barely used the app, and there was no comparison group. Key Findings 56 …

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Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

TL;DR: Pooling 59 trials, all from China, researchers found that adding acupuncture or electroacupuncture to standard rehab after a stroke was linked to better leg movement scores for people with foot drop. But the studies varied widely and many had quality problems, so the size of the benefit is uncertain. Key Findings 59 trials, 4,596 …

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Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

TL;DR: In 10 young adults with a neck-level spinal cord injury, standing upright in a frame made blood pressure drop. Wearing compression stockings and a belly binder kept blood pressure from falling, and the five people who felt faint said they felt better. Key Findings Standing lowered blood pressure: Pressure and pulse pressure fell significantly …

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