TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials from null trials in retrospective power analyses. Key Findings Six phase III trials: Researchers retrospectively simulated TRAILBLAZER-ALZ2, CLARITY AD, EMERGE, …
TL;DR: A 2026 study in the Journal of Eating Disorders found that higher sensation seeking, a personality trait involving pursuit of novel or intense experiences, was linked to more restraint and overeating in 400 German adolescents, with stronger disordered-eating links in teens with higher BMI, hyperactivity/inattention, emotional symptoms, or peer problems. Key Findings 400 adolescents: …
TL;DR: A 2026 longitudinal study in Personality and Individual Differences followed 346 Turkish young adults across two survey waves three months apart and found that childhood psychological abuse predicted lower adult relationship satisfaction, with a reduced sense of belonging acting as the statistical mediator linking the early adversity to the later romantic outcome. Key Findings …
TL;DR: A 12-month four-wave longitudinal study in Psychological Science (N=2,149 adults across the UK, US, Canada, and Australia) found that feeling more emotionally isolated predicted higher chatbot use four months later — and that higher chatbot use, in turn, predicted further increases in emotional isolation at the next wave. Key Findings Bidirectional link with emotional …
TL;DR: A 2026 exploratory study in Nature Communications found that a first 25 mg psilocybin dose in 28 psychedelic-naive adults increased electroencephalography (EEG), a scalp recording of brain electrical activity, entropy during the acute session and that entropy predicted one-month well-being change. Key Findings 28 psychedelic-naive adults: Participants received 1 mg psilocybin as a low-dose …
TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health found that depression symptoms, alcohol use, and alcohol use disorder (AUD) symptoms were not associated with C-reactive protein (CRP), a blood inflammation marker, or a pro-inflammatory cytokine index in 972 community adults, and twin analyses suggested familial confounding explained several cytokine-AUD links. Key Findings …
TL;DR: A 2026 study in JAMA Network Open tracked 1,338 older adults from the Rush Memory and Aging Project for up to 19 years using objective wrist-actigraphy and found that each additional hour of daytime napping per day was linked to ~13% higher mortality, each extra nap per day to ~7% higher mortality, and morning …
TL;DR: A 2026 study in Nature Neuroscience from Baylor College of Medicine showed that boosting Sox9, a transcription factor that regulates aging astrocytes, improved astrocytes’ ability to clear amyloid plaques in Alzheimer’s mouse models and preserved cognitive function — pointing to a treatment strategy that targets the brain’s own support cells rather than directly attacking …
TL;DR: A 2026 study in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences measured a monocyte-specific DNA methylation clock (MonoDNAmAge) in 440 women with and without HIV, and found that accelerated monocyte epigenetic aging was specifically linked to non-somatic depressive symptoms (anhedonia, hopelessness, cognitive impacts) but not to broader depression severity, supporting …
TL;DR: A 2026 longitudinal study in Appetite following 491 Quebec children found that infants breastfed for at least three to six months showed better inhibitory control — the ability to suppress an automatic response — at age three and a half than infants who were never breastfed, with the largest behavioral benefits in those breastfed …
