TL;DR: In a small Pakistan pilot, 23 of 25 adults given an Urdu version of a talk therapy for anxiety and depression finished all 14 weeks. The trial was too small to show the therapy works. Key Findings Signed up and stayed: 51 adults were randomly assigned to therapy or a waitlist. 42 of 51 …
TL;DR: Across 55 trials in low- and middle-income countries (5,041 adults), people who got therapy had much lower PTSD symptoms than people on a wait-list or other comparison. The evidence was very low certainty because many trials were weakly run. Key Findings Big gap after treatment: PTSD symptoms 1.31 standard deviations lower in therapy groups …
TL;DR: In a pooled review of 8 studies of 980 people with depression and sleep problems, sleep tests showed more deep sleep and less light sleep after taking trazodone than before. Compared with placebo, though, the deep-sleep gain was not clear, and drowsiness and dizziness were more common. Key Findings 8 studies, 980 people: 5 …
TL;DR: Across 5 small trials of 343 people after stroke, people who sat in bright morning light reported better sleep quality than comparison groups. But measured time awake at night showed no clear change, so the benefit may be more about how sleep feels. Key Findings 5 trials, 343 people: All gave light in the …
TL;DR: A therapy app did not reduce depression scores more than a look-alike education app in a trial of adults with past concussions. Insomnia scores improved more with the therapy app, but only 42 of 113 participants completed the main 12-week check-in. Key Findings No edge on depression: Over 12 weeks, depression scores fell 2.0 …
TL;DR: Women who reported 10+ brain injuries from a partner performed on a speed test like someone about 21 years older than their actual age. They scored about 11 years “older” than survivors with no brain injury; the study of 207 women found a link, not proof that the injuries caused the difference. Key Findings …
TL;DR: A 2026 pooled analysis in CNS Drugs combined two six-week trials of adults whose depression hadn’t responded well enough to an antidepressant. Adding the antipsychotic lumateperone instead of a placebo raised the share of people with side effects from 45.1% to 68.1% and the share who quit because of them from 0.8% to 8.7%. …
TL;DR: A 2026 meta-analysis in Neurological Sciences pooled 10 studies that gave people with Parkinson’s disease, tested while on their dopamine medication, and healthy adults the same “think of as many ideas as you can” tasks. On average, the two groups scored about the same, with neither a creative boost nor a clear deficit. Key …
TL;DR: A meta-analysis pooling 63 studies and 265,079 people found that cannabis users had about twice the odds of committing violence as non-users (2.05 times in the general population, 2.49 times among psychiatric patients). The gap shrank to 1.17 times in studies that followed people over time. The design shows an association, not that cannabis …
TL;DR: In an online survey of 126 mothers of toddlers in Taiwan, mothers who reported more depressive symptoms also tended to describe their toddler’s sleep as more of a problem and to report longer times to fall asleep. The link with perceived sleep problems showed up in families where the toddler shared a sleeping surface …
