Astrocyte BMP Suppression Reduced Audiogenic Seizures in Fragile X Mice
TL;DR: Fragile X is usually framed as a neuronal disease. A new mouse study points the finger somewhere else: an overactive BMP signaling program inside astrocytes. Switching it off in glial cells alone — by deleting Smad4 — reduced sound-triggered seizures and partially restored synaptic activity in the auditory cortex. Key Findings The intervention was …
