Complex PTSD Therapy Meta-Analysis Finds No One Required Sequence

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Complex PTSD Therapy Meta-Analysis Finds No One Required Sequence

TL;DR: A 2026 systematic review and meta-analysis in European Journal of Psychotraumatology found that phase-based therapy was not clearly better than non-phase-based therapy for most complex PTSD outcomes, although multi-phase treatment had stronger PTSD effects and phase/exposure-based approaches improved affect dysregulation more. Key Findings Sixteen randomized trials were included: Researchers reviewed psychological interventions for complex …

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Smoking and Quitting Shifted Clozapine Metabolism in Schizophrenia

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Smoking and Quitting Shifted Clozapine Metabolism in Schizophrenia

TL;DR: A 2026 study in Neuropsychopharmacology Reports found that repeated cigarette smoking and quitting shifted clozapine metabolism in one Japanese man with treatment-resistant schizophrenia, with the dose-adjusted clozapine level falling during smoking periods. Key Findings One patient was followed across five periods: Researchers tracked a Japanese man in his 40s across smoking, quitting, smoking, quitting, …

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NYUCI-ES Adapted Dementia Caregiver Counseling for Chinese and Korean American Families

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NYUCI-ES Adapted Dementia Caregiver Counseling for Chinese and Korean American Families

TL;DR: A 2026 descriptive study in JMIR Formative Research reported that the NYUCI-ES dementia-caregiver program required 24 documented cultural adaptations before and during delivery to Chinese and Korean American caregivers. Key Findings 24 adaptation strategies: Researchers identified 24 major changes to the dementia-caregiver intervention. Five adaptation elements: Changes were grouped into content, context, relationship fidelity, …

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Childhood Poverty and Inhibitory Control Split Behavioral Risk Patterns

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Childhood Poverty and Inhibitory Control Split Behavioral Risk Patterns

TL;DR: A 2026 preprint in medRxiv using ABCD Study data found that childhood poverty strengthened the link between early-life adversity and later behavioral problems, while inhibitory-control brain and temperament profiles separated higher- and lower-risk patterns within poverty-exposed youth. Key Findings 10,112 youth were analyzed: Researchers used the Adolescent Brain Cognitive Development Study to link baseline …

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Childhood Blood Proteome Shifted With Age and Sex in Longitudinal Study

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Childhood Blood Proteome Shifted With Age and Sex in Longitudinal Study

TL;DR: A 2026 Nature Communications study followed 100 Swedish participants from age 4 to 24 and found that more than half of detectable blood proteins changed with age, with sex-related protein differences becoming much larger by adolescence and early adulthood. Key Findings Four repeated blood draws: Researchers measured plasma proteins at ages 4, 8, 16, …

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Three Childhood ADHD Dimensions Each Predicted Distinct Adult Mood-Disorder Profiles in 755 Patients

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Three Childhood ADHD Dimensions Each Predicted Distinct Adult Mood-Disorder Profiles in 755 Patients

TL;DR: A 2026 study in European Archives of Psychiatry and Clinical Neuroscience of 755 Korean adults with mood disorders found that three distinct childhood ADHD traits each tracked with different adult clinical features, suggesting ADHD’s influence on mood-disorder presentation is dimension-specific rather than uniform. Key Findings Mood-disorder profiles split by ADHD trait: Researchers analyzed 755 …

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Centaur AI Model Passed Psychology Tests Without Following New Instructions

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Centaur AI Model Passed Psychology Tests Without Following New Instructions

TL;DR: A 2026 study in National Science Open argued that Centaur, an AI model promoted as a simulator of human cognition, could reproduce psychology-test answers while failing a simple instruction-understanding check. Key Findings Centaur was tested as a cognition simulator: the earlier model reportedly performed well across 160 psychology tasks, including decision-making and executive-control experiments. …

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CBT-I Trial Will Test Sleep Treatment in Treatment-Resistant Schizophrenia

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CBT-I Trial Will Test Sleep Treatment in Treatment-Resistant Schizophrenia

TL;DR: A 2026 study protocol in Trials describes COSTS, a randomized trial that will compare cognitive behavioral therapy for insomnia (CBT-I) with standard cognitive behavioral therapy (CBT) in 60 people with treatment-resistant schizophrenia and persistent sleep disturbance. Key Findings Planned sample: Researchers aim to enroll 60 adults with treatment-resistant schizophrenia or related chronic psychosis plus …

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CBD Psychiatric Claims Need Standardized Products and Safety Monitoring

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CBD Psychiatric Claims Need Standardized Products and Safety Monitoring

TL;DR: A 2026 paper in Neuropsychopharmacology argued that cannabidiol (CBD), a non-intoxicating cannabis compound, has plausible psychiatric and neurological uses, but clinical claims need standardized products, exposure tracking, and safety monitoring before retail CBD can be treated like medicine. Key Findings Epilepsy evidence is strongest: Approved prescription CBD has the clearest support in rare pediatric …

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Catecholamine GPCR Ligand Selectivity Was Swapped by Small Residue Sets

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Catecholamine GPCR Ligand Selectivity Was Swapped by Small Residue Sets

TL;DR: A 2026 Nature Communications study found that small sets of amino-acid changes could swap ligand preference between beta2 adrenergic and D1 dopamine receptors, showing that receptor selectivity depends on both the binding pocket and surrounding structural interfaces. Key Findings 120 receptor mutants: Researchers tested 120 engineered catecholamine receptor mutants across beta2 adrenergic and D1 …

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