TL;DR: A 2026 Journal of Health Psychology study found body roundness index (BRI), a waist-and-height shape measure, identified dementia patients with higher odds of depressive symptoms better than body mass index did. Key Findings Threefold higher odds in the top BRI quartile: Among dementia patients, those in the highest body-roundness quartile had more than 3ร …
TL;DR: A 2026 Hong Kong Markov model in PLOS Medicine found esketamine improved treatment-resistant depression outcomes but was not cost-effective against cheaper third-line options under current payer assumptions. Key Findings Antidepressant combination therapy was lowest-cost: One antidepressant plus another antidepressant cost US$16,163 per patient and produced 2.903 QALYs, the most cost-effective strategy in the model. …
TL;DR: A 2026 crossover trial in Journal of Korean Medical Science found hearing aids outperformed PSAPs over 3 months, especially for high-frequency speech clarity, speech-in-noise, and continued device use. Key Findings Only hearing aids improved 4,000โ6,000 Hz hearing: Both device classes helped 250โ3,000 Hz, but the high frequencies that carry consonants โ “s,” “f,” “th” …
TL;DR: A 2026 bioRxiv preprint found repeated low-intensity focused ultrasound in Alzheimer’s rats changed blood-brain-barrier and microglial biology but did not clearly improve Alzheimer’s pathology on its own. Key Findings Day 7 after 4 weekly sessions: Aฮฒ42 and pTau231 went the wrong way: Aggregated Aฮฒ42 rose (p = 0.0059), pTau231 rose (p = 0.0009). Repeated …
TL;DR: A 2026 Molecular Psychiatry study found ethanolamine in cerebrospinal fluid (CSF) was lower during active major depression, increased after electroconvulsive therapy, replicated across 4 sites, and tracked with symptom severity. Key Findings Active depression: 12.32 vs 14.07 ยตM: Active MDD patients had lower CSF ethanolamine than healthy controls (p = 0.00047) in a 380-person …
TL;DR: A 2026 Circulation Research study found a brainstem expiratory-neuron circuit raised blood pressure in neurogenic hypertension models, and silencing that circuit brought pressure back toward normal. Key Findings Inactivation normalized blood pressure: Silencing the lateral parafacial region restored blood pressure to normal levels in the reported hypertensive model โ the strongest causal piece of …
TL;DR: A 2026 review of 54 randomized trials in The Lancet Psychiatry found evidence remains too weak to support routine cannabinoid treatment for common mental disorders, despite widespread use for anxiety, PTSD, sleep, and substance-use symptoms. Key Findings 54 RCTs, 2,477 participants total: Sounds substantial โ until split across many disorders, compounds, doses, and outcomes. …
TL;DR: A 2025 Journal of Personality study found that reactivating autonomy-frustrating memories made COVID conspiracy claims more believable, enraging, and shareable in two Quebec experiments. Key Findings Subliminal memory cues moved real beliefs: Memory keywords flashed for just 60 ms โ too fast for conscious reading โ increased bogus-conspiracy endorsement, anger, and willingness to share. …
TL;DR: A 2026 randomized trial in The British Journal of Psychiatry found 6 ketamine infusions improved severe treatment-resistant depression, but curated music added no measurable benefit; higher mystical-experience scores still predicted the next session’s depression outcome. Key Findings MADRS fell 11.8 points by week 4: Scores dropped from 31.5 to 19.7 (d = 1.2, p …
TL;DR: A 2026 World Journal of Biological Psychiatry study found brain-wave connectivity between a prefrontal control area and a depression-linked cingulate region differed in patients who later remitted after rTMS magnetic stimulation. Key Findings Remitters had lower pre-treatment DLPFC-to-sgACC alpha connectivity: Baseline alpha-band isolated effective coherence (iCoh) โ a directional measure โ from left DLPFC …
