Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

Depression Prevention App Pilot: Predicted Risk and Anxiety Fell, but Depression Symptoms Did Not and Few Used It

TL;DR: In a small Spanish pilot, adults at high risk of depression got a personalized prevention plan from their family doctor plus an app. After 3 months their predicted depression risk and anxiety scores fell, but depression symptoms did not, most people barely used the app, and there was no comparison group. Key Findings 56 …

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Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

Acupuncture Added to Rehab May Improve Movement in Stroke Foot Drop, but the Evidence Is Uneven

TL;DR: Pooling 59 trials, all from China, researchers found that adding acupuncture or electroacupuncture to standard rehab after a stroke was linked to better leg movement scores for people with foot drop. But the studies varied widely and many had quality problems, so the size of the benefit is uncertain. Key Findings 59 trials, 4,596 …

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Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

Compression Stockings and Belly Binder May Keep Blood Pressure Steady When Standing After Neck Spinal Cord Injury

TL;DR: In 10 young adults with a neck-level spinal cord injury, standing upright in a frame made blood pressure drop. Wearing compression stockings and a belly binder kept blood pressure from falling, and the five people who felt faint said they felt better. Key Findings Standing lowered blood pressure: Pressure and pulse pressure fell significantly …

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Brief Force Bursts in the Head During Sleep Were Less Frequent in People With Brain Disease, Preprint Finds

Brief Force Bursts in the Head During Sleep Were Less Frequent in People With Brain Disease, Preprint Finds

TL;DR: A headband sensor picked up brief bursts of force inside the head during sleep in all 45 people tested. People with neurodegenerative diseases had fewer bursts per minute than healthy volunteers, in an early, not yet peer-reviewed study. Key Findings A new sleep signal: 1- to 2-second “sleep bursts” showed up in every one …

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Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

Seizures Were the Most Common First Sign of PRES Brain Swelling in Children, 20-Year Review Finds

TL;DR: At a leading London children’s hospital, 77 children with PRES, a sudden brain-swelling syndrome, were reviewed over 20 years. Nearly 4 in 5 first showed up with seizures, almost all had another serious illness, and about a third of those given seizure medicine still needed it after 6 months. Key Findings Seizures came first: …

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After a Hip Fracture, Dementia and a Low Nutrition Score Linked to Not Walking Independently at Discharge

After a Hip Fracture, Dementia and a Low Nutrition Score Linked to Not Walking Independently at Discharge

TL;DR: Among older adults who walked on their own before breaking a hip, those with dementia or a low blood-based nutrition score a week after surgery were less likely to be walking independently when they left the hospital. The nutrition score alone was only a rough predictor. Key Findings Half lost independence: 88 of 173 …

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Autoimmune LGI1 Encephalitis Linked to Brain Changes Far Beyond Memory Centers

Autoimmune LGI1 Encephalitis Linked to Brain Changes Far Beyond Memory Centers

TL;DR: In a German study of 34 people recovering from LGI1 encephalitis, a rare autoimmune brain disease, brain scans showed changes well beyond the memory centers usually blamed. People with more of these changes had poorer thinking scores and recovered less. Key Findings Most improved: Median disability score fell from 3 at the worst point …

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Dichloroacetate Missed Its Main Goal in Kids With Rare Energy Disorder PDCD, but Lowered Lactate

Dichloroacetate Missed Its Main Goal in Kids With Rare Energy Disorder PDCD, but Lowered Lactate

TL;DR: In a phase III trial of 34 children with a rare inherited energy disorder, the drug dichloroacetate did not improve parent-rated movement problems more than placebo over 4 months. It did lower a harmful blood acid, lactate, and was well tolerated. Key Findings Main goal missed: Movement scores did not differ from placebo (p …

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Strength Training May Speed Up Walking in Early Parkinson’s, but Added Brain Tasks Show No Extra Edge

Strength Training May Speed Up Walking in Early Parkinson's, but Added Brain Tasks Show No Extra Edge

TL;DR: In a small Spanish trial, people with early Parkinson’s who did 12 weeks of strength training, with or without added thinking tasks, got faster on a walking test and stronger on a chair-stand test than people who did not exercise. Adding the thinking tasks gave no clear extra benefit. Key Findings 24 people, 3 …

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Heart Failure Linked to Lower Thinking Scores and a Brain Fluid-Flow Change on MRI

Heart Failure Linked to Lower Thinking Scores and a Brain Fluid-Flow Change on MRI

TL;DR: People with a common type of heart failure scored lower on thinking tests than healthy people of similar age, and an MRI sign of the brain’s fluid-clearing system was lower on the left side of their brains. Lower values of that sign went with lower thinking scores. Key Findings Lower thinking scores: Average MoCA …

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