TL;DR: A 2026 preprint in medRxiv linked higher neighborhood deprivation to faster DNA-methylation aging in 370 healthy adults, with lifetime adversity explaining part of the association and stronger direct effects among Black participants. Key Findings Yale sample anchored the test: The cross-sectional Yale Stress Center sample included 370 adults aged 18 to 50 years without …
TL;DR: A 2026 nationwide claims study in Integrative Medicine Research found that Korean traditional medicine care without recorded acupuncture claims had the lowest modeled costs and the highest 3-year QALYs among four menopausal-disorder treatment strategies, while acupuncture and integrative-care groups appeared to include sicker, higher-utilization patients. Key Findings 32,941 women: The retrospective cohort used Korean …
TL;DR: A 2026 open-label feasibility trial in IBRO Neuroscience Reports tested an AI-guided variable levodopa schedule in 5 people with Parkinson’s disease and found 4 patients improved on UPDRS, but the study was far too small and uncontrolled to prove efficacy. Key Findings Feasibility sample: The single-center trial enrolled 5 people with Parkinson’s disease after …
TL;DR: A 2026 study in Cognitive, Affective, & Behavioral Neuroscience used functional MRI (fMRI) to show that adults made more socially mindful choices for political ingroup members than for outgroup or unclassified partners. Key Findings The fMRI task tested group-identity cues: 45 adults with strong pro- or anti-refugee stances made choices for ingroup, outgroup, or …
TL;DR: A 2026 randomized trial in Nature and Science of Sleep found that Sancai acupoint acupuncture reduced primary-insomnia severity more than sham acupuncture, with parallel improvements in sleep testing and peripheral 5-HT and BDNF biomarkers. Key Findings 76-person insomnia trial: Researchers randomized 38 patients to real Sancai acupuncture and 38 to sham acupuncture. 20 treatment …
TL;DR: A 2026 preprint in medRxiv linked recurrent major depression to direction-specific effective-connectivity changes, with strongest patterns in cerebellar-cortical, sensorimotor, cognitive, neurotransmitter, and oligodendrocyte precursor cell maps. Key Findings 1,627-person discovery dataset: REST-meta-MDD resting-state functional MRI (fMRI) and T1 MRI data compared 839 people with major depression and 788 controls. Recurrent depression pattern: First-episode drug-naive …
TL;DR: A 2025 human proteomics study in Molecular Metabolism found that about 10 days of medically supervised water-only fasting caused weight loss and lower circulating amyloid beta proteins, but also increased inflammatory and platelet-activation markers. Key Findings 20 volunteers: The main cohort included 20 middle-aged adults with mean age 52.2 years and mean BMI 28.8 …
TL;DR: A 2026 study in BJPsych Open found that closely monitored antidepressant care improved quality of life and reduced societal costs in both PReDicT and usual-care groups, while the PReDicT algorithm added uncertain, country-dependent economic value. Key Findings Multinational trial data anchored the analysis: The economic evaluation followed 913 patients in France, Germany, the Netherlands, …
TL;DR: A 2026 study in Radiology Case Reports described a 14-year-old boy whose seizure workup found a rare congenital left parahippocampal herniation on MRI, with imaging features that favored a benign developmental variant rather than tumor or acute brain herniation. Key Findings One adolescent case: The report involved a previously healthy 14-year-old boy evaluated after …
TL;DR: A 2026 methods paper in Nature Methods describes Neuropixels Opto probes that combine high-density neural recording with spatially addressable blue and red optogenetic stimulation in 1 mouse-brain device. Key Findings 960 recording sites: Each prototype probe packed 960 electrical sites on a 70-micrometer-wide, 1-centimeter-long shank. 28 light emitters: Two sets of 14 emitters delivered …
