TL;DR: A 2026 preprint in medRxiv found that deep brain stimulation for severe obsessive-compulsive disorder was followed by lower globus pallidus externus alpha-band activity in clinically responsive patients, suggesting a possible brain readout of sustained DBS response. Key Findings 10 severe OCD patients: Researchers recorded local field potentials from the anterior globus pallidus externus (GPe) …
TL;DR: A 2026 mouse study in The Journal of Physiology found that damaging noise temporarily disrupted sound-offset responses in a brainstem hearing circuit, but those timing responses partly recovered within 24 hours through rapid circuit adaptation. Key Findings Sound-offset responses mark when sound ends: researchers studied neurons in the superior paraolivary nucleus (SPN), a brainstem …
TL;DR: A 2026 study in European Journal of Social Psychology found that adding flattering Nazi-era propaganda images to atrocity photographs reduced several immediate negative emotions in German viewers across the combined evidence, even though the clearest guilt effect did not replicate in the online sample. Key Findings Mixed-image condition: Participants saw atrocity photographs alone or …
TL;DR: A 2026 study in The British Journal of Psychiatry found that a single 50 mg dose of naltrexone reduced distress and shifted threat-related brain activity without blocking people’s ability to reappraise negative images. Key Findings 38 healthy volunteers completed a placebo-controlled crossover: Participants received naltrexone 50 mg and placebo on separate visits, then performed …
TL;DR: A 2026 Molecular Psychiatry study tested Regional Vulnerability Index for Alzheimer’s disease (RVI-AD), a structural-MRI score of how closely a person’s brain pattern resembles amyloid-positive Alzheimer’s disease, and found that higher RVI-AD predicted conversion from mild cognitive impairment to dementia most strongly in the first 3 years. Key Findings 571-person reference map: Researchers built …
TL;DR: A 2025 study in Journal of the American Chemical Society found that a depression-linked gut bacterium now has a concrete inflammatory mechanism: Morganella morganii can make unusual phospholipids that activate TLR2/TLR1 and drive IL-6. Key Findings Morganella got a molecule: The paper moved beyond a microbiome correlation by isolating pro-inflammatory metabolites made by M. …
TL;DR: A 2026 Research Square preprint used silent verb-generation functional MRI (fMRI), brain imaging during covert word production, and found early cerebellar-cerebral language-network changes after radiotherapy in 31 children and adolescents treated for medulloblastoma. Key Findings 31 pediatric patients: Children and adolescents with medulloblastoma completed silent verb-generation fMRI before radiotherapy and again within 6 weeks …
TL;DR: A 2026 medRxiv preprint reanalyzed long-term survivors from the AB10015 ALS trial and reported that masitinib-treated patients had higher 5-year survival than historical benchmarks, but the analysis was post hoc, sponsor-supported, and lacked long-term placebo follow-up. Key Findings Five-year survival was 42.3%: 55 of 130 patients assigned to masitinib 4.5 mg/kg/day were alive at …
TL;DR: A 2026 network meta-analysis in International Clinical Psychopharmacology found that lurasidone and xanomeline-trospium improved global cognitive scores in schizophrenia-spectrum randomized trials, while quetiapine and cariprazine ranked best for attention. Key Findings 14 randomized trials: Researchers analyzed 2,464 participants across trials of selected second- and third-generation antipsychotics plus xanomeline-trospium. Lurasidone improved global cognition: Lurasidone outperformed …
TL;DR: A 2026 medRxiv preprint reported that bedside 64 mT portable MRI scans from ECMO patients could support brain-volume analysis, with segmented volumes broadly comparable to conventional MRI and low-field MRI scans without ECMO equipment. Key Findings 30 ECMO scans: The volumetric pipeline analyzed T2-weighted portable MRI scans from 30 patients receiving extracorporeal membrane oxygenation. …
