Language and Theory of Mind Brain Systems Were Already Distinct in 3- to 9-Year-Old Children

Language and Theory of Mind Brain Systems Were Already Distinct in 3- to 9-Year-Old Children

TL;DR: A 2026 Communications Biology fMRI study found that language and theory of mind, the ability to infer other people’s mental states, were already neurally distinct in children aged 3-9 rather than slowly separating during development. Key Findings Children show distinct neural specificity for language and theory of mind in superior temporal lobe — just …

Read more

Intestinal Epithelial Serotonin Reduced Anxiety and Depression-Like Behavior via Vagus in Mice; In Utero SSRI Linked to Infant Constipation

Intestinal Epithelial Serotonin Reduced Anxiety and Depression-Like Behavior via Vagus in Mice; In Utero SSRI Linked to Infant Constipation

TL;DR: A 2024 Gastroenterology study found that intestinal epithelial serotonin reduced anxiety- and depression-like behavior in mice through vagal signaling, while prenatal SSRI exposure in a human cohort predicted infant functional constipation independent of maternal depression. Key Findings Gut-only serotonin reuptake transporter ablation reduced anxiety and depression-like behavior: Targeting SERT only in the intestinal epithelium …

Read more

Hypothalamic LPO-BDNF Neurons Deepened Anesthesia and DMH Glutamate Neurons Accelerated Emergence in Mice

Hypothalamic LPO-BDNF Neurons Deepened Anesthesia and DMH Glutamate Neurons Accelerated Emergence in Mice

TL;DR: A 2026 mouse study in iScience found that anesthetic emergence slowed sharply below 31.9°C because two hypothalamic thermoregulatory pathways pushed anesthesia in opposite directions: preoptic BDNF neurons deepened anesthesia, while a dorsomedial-hypothalamus-to-raphe-pallidus glutamate pathway accelerated emergence. Key Findings Emergence delay grows logarithmically below 31.9°C core temperature: In mice, anesthetic emergence time increases logarithmically as …

Read more

Ex-Smokers Had Higher Food Cue Reactivity on fMRI

Ex-Smokers Had Higher Food Cue Reactivity on fMRI

TL;DR: A 2026 medRxiv preprint found that ex-smokers had higher fMRI blood oxygen level dependent (BOLD) responses to high-energy food pictures than adults with obesity or abstinent alcohol dependence, suggesting a brain reward route for post-quitting weight gain. Key Findings 77-person fMRI comparison: Researchers compared 25 ex-smokers, 26 abstinent adults with alcohol dependence, and 26 …

Read more

Early-Life Visceral Stress Sensitized Auditory Brainstem and Altered Cochlear Proteome in Rat IBS Model

Early-Life Visceral Stress Sensitized Auditory Brainstem and Altered Cochlear Proteome in Rat IBS Model

TL;DR: A 2026 rat study in Neurobiology of Stress found that early-life visceral stress produced adult IBS-like symptoms alongside auditory brainstem sensitization and cochlear protein changes, giving a mechanistic explanation for sound sensitivity reported by some IBS patients. Key Findings Early-life visceral stress sensitized the auditory brainstem: Rats exposed to early-life visceral stress (the standard …

Read more

Braless State Increased Attractiveness Ratings but Lowered Faithfulness Ratings

Braless State Increased Attractiveness Ratings but Lowered Faithfulness Ratings

TL;DR: A 2026 study in Frontiers in Psychology found that braless images were rated as more attractive but less faithful, while women who feared sexual harassment reported being less likely to go braless in public. Key Findings 409 Slovak women surveyed: Researchers asked women about bra wearing in public and private settings, body-related factors, sexual …

Read more

Big Five Personality Traits Predicted Sexual Fantasy Frequency

Big Five Personality Traits Predicted Sexual Fantasy Frequency

TL;DR: A 2026 study in PLOS One found that Big Five personality traits were linked to how often 5,225 partnered adults reported sexual fantasies: conscientiousness and agreeableness predicted lower fantasy frequency, while the depression facet of negative emotionality predicted higher frequency. Key Findings Partnered adult sample: researchers surveyed 5,225 partnered adults recruited through Qualtrics Panels, …

Read more

Three Molecular Autism Subtypes Identified With Distinct Phenotypes via Transcriptomic Analysis

Three Molecular Autism Subtypes Identified With Distinct Phenotypes via Transcriptomic Analysis

TL;DR: A 2026 Communications Biology transcriptomic analysis identified three molecular subtypes of autism spectrum disorder, each linked to a distinct phenotypic profile and biological pathway pattern. Key Findings Three molecular subtypes emerged from transcriptomic analysis: Researchers identified three distinct molecular subtypes of autism spectrum disorder using transcriptomic data, each with its own gene expression signature. …

Read more

Autism Polygenic Scores Predicted Lower Brain Neurite Density in 36,000 People

Autism Polygenic Scores Predicted Lower Brain Neurite Density in 36,000 People

TL;DR: A 2025 Molecular Psychiatry study of more than 36,000 people found that higher autism polygenic risk was associated with lower MRI-derived neurite density, a measure of neural-fiber packing, across cortex and white matter in both children and adults. Key Findings Higher autism polygenic score predicted lower neurite density: Across over 36,000 individuals, a robust …

Read more

Adolescent THC Exposure Produced Adult Anxiety and Cognitive Deficits in Male Rats

Adolescent THC Exposure Produced Adult Anxiety and Cognitive Deficits in Male Rats

TL;DR: A 2026 rat study in Psychopharmacology found that THC exposure during late adolescence left adult animals with elevated anxiety-like behavior and impaired object-recognition and spatial-memory performance after a drug-free recovery period. Key Findings Adolescent THC exposure produced lasting anxiety-like behavior in adulthood: Rats given THC (5 mg/kg/day) from postnatal day 42 to 62 (late …

Read more