LIT-001 (Oxytocin Receptor Agonist) Alters Pair Bonding in Prairie Voles (2024 Study)
A small-molecule oxytocin receptor-specific agonist, LIT-001, differentially affects the acquisition and expression of partner preference in prairie voles, enhancing bonding when administered before cohabitation but inhibiting it when given afterward. Highlights: LIT-001 Enhances Bonding Pre-Cohabitation: Administration of LIT-001 (10 mg/kg) before a 4-hour cohabitation period facilitated the acquisition of partner preference in male prairie voles. …