TL;DR: A 2026 mouse study in Translational Psychiatry reported that six days of adolescent THC exposure reduced Reelin-positive cell density in the female prefrontal cortex and cortical thickness across sexes. Prenatal immune activation did not consistently magnify the effects, and the short-term animal experiment does not show that cannabis causes schizophrenia in people. Key Findings …
TL;DR: A 2026 medRxiv preprint linked greater attention-deficit/hyperactivity disorder (ADHD) symptom scores in college students to reduced stop-signal functional MRI (fMRI) activation in cannabinoid receptor 1 (CB1R)-rich brain regions, and that reduced activation predicted heavier cannabis-use trajectories over 4 years. Key Findings ADHD-cannabis trajectory: Researchers analyzed cannabis-use trajectories in 466 first-year college students aged 18-19, …
TL;DR: A 2026 systematic review and meta-analysis in Molecular Psychiatry found that CB-1 receptor blockade and cannabidiol reduced alcohol intake in animal models, but human alcohol-use-disorder evidence remained inconsistent and too thin to support a treatment claim. Key Findings 63 studies reviewed: Researchers synthesized 44 preclinical studies and 19 clinical or human experimental studies of …
Cannabinoids Had Weak Evidence for Mental Disorders TL;DR: A Lancet Psychiatry review of randomized trials found little support for routine cannabinoid treatment in common mental disorders, despite possible weak signals in a few narrower conditions. Key Findings 54 randomized controlled trials were reviewed: The analysis covered 2,477 participants across mental disorders and substance-use disorders. Routine …
Cannabis Did Not Just Blur Word Lists. It Hit Everyday Memory Too TL;DR: A randomized vaporized-THC trial found broad acute memory impairment, including false memories, prospective memory, source memory, and temporal order memory, with no meaningful dose split between 20 and 40 mg. Key Findings 120 regular cannabis users randomized: Participants vaporized placebo cannabis, 20 …
Individuals at risk for cannabis use disorder (CUD) exhibit increased dynamic fluidity and altered connectivity patterns in brain networks, suggesting early changes in brain function that may contribute to cannabis addiction risk. Highlights: At-risk individuals for cannabis addiction show a greater number of meta-states and more frequent transitions between them, indicating higher dynamic fluidity in …
Cannabidiol (CBD) has recently emerged as a popular supplement among athletes looking to enhance recovery and performance. Key facts about CBD: CBD is a natural compound extracted from cannabis/hemp plants It does not cause psychoactive effects like THC CBD interacts with the body’s endocannabinoid system to produce potential benefits Athletes use CBD hoping to improve …
A powerful, unregulated synthetic marijuana called “Tiburón” (Spanish for “shark”) has recently emerged in Honduras, posing severe risks to public health. Produced and sold by the notorious MS-13 street gang, this altered cannabis strain is designed to be even more addictive than regular marijuana. But its exact contents and effects remain a mystery. Key Facts: …
Cannabidiol (CBD) is emerging as a promising therapeutic for a variety of health conditions, but research is still in early stages. Here are some key facts on purified CBD: Purified CBD is showing positive results in clinical trials for anxiety, psychosis, schizophrenia, PTSD and substance abuse. Evidence is strongest in these neurological and psychiatric conditions. …
Cannabis hyperemesis syndrome (CHS) is a newly recognized condition causing severe nausea and vomiting in long-term cannabis users. Key facts about CHS: Repeated, uncontrollable vomiting is the main symptom Occurs in long-term heavy cannabis users Exact cause is unknown, but likely involves cannabis effects on brain receptors Stopping cannabis use is the only definitive cure …
