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AlzheimersJuly 9, 2026

Brain-Derived Plasma pTau217 Better Predicted Near-Term Amyloid PET Progression

TL;DR: A 2026 ADNI analysis posted to medRxiv found that brain-derived plasma pTau217 better predicted near-term amyloid positron emission tomography (PET) positivity than total plasma pTau217 in cognitively unimpaired amyloid-negative participants. Key Findin…

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AlzheimersMay 11, 2026

SimulAD Modeled Amyloid Clearance in Alzheimer’s Trials

TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials fro…

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Brain-Derived Plasma pTau217 Better Predicted Near-Term Amyloid PET Progression

SimulAD Modeled Amyloid Clearance in Alzheimer’s Trials

The findings. The context. The caveats.