Genetic Loci

Shared Genes & Biological Pathways in Depression & Alzheimer’s Disease (2024 Study)

by

A study found shared brain-specific mechanisms between Alzheimer’s disease (AD) and depression, particularly involving synaptic signaling and immune system pathways in the hippocampus, but no direct genetic overlap. Highlights: Six brain-specific eQTL genes (SRA1, MICA, PCDHA7, PCDHA8, PCDHA10, PCDHA13) are shared between AD and depression. Pathway analysis identified shared biological pathways, including synaptic signaling, myelination, …

Read more

Genetic Predisposition to Loneliness: Is Your DNA to Blame?

by

Loneliness is a painful feeling that arises when there is a mismatch between one’s desired social connections and actual relationships. Chronic loneliness is increasingly prevalent in modern societies and strongly tied to poor mental and physical health outcomes, including higher risks of depression, cardiovascular disease, and mortality. New genetic research provides key insights into the …

Read more