AI-Assisted Bayesian Inference Found Gamma-Secretase Alzheimer Pathways
TL;DR: A 2026 medRxiv preprint applied ChatGPT-4o-assisted Bayesian-frequentist hybrid inference to Alzheimer’s single-nucleus RNA-seq data and identified gamma-secretase and HP1 transcription pathways that a no-evidence frequentist setting did not recover. Key Findings 427 ROSMAP samples: The application used postmortem prefrontal cortex single-nucleus RNA-seq data from 427 Religious Orders Study and Memory and Aging Project samples. …
