Minocycline Adjunct Treatment for Depression via Immune-Inflammation Effects

Major depressive disorder (MDD) is a highly prevalent and debilitating condition. Novel treatment approaches are needed, especially for individuals with treatment-resistant depression. This study investigated the effects of adjunctive minocycline on immune-inflammatory biomarkers and clinical outcomes in MDD. Key Highlights: Minocycline is a broad-spectrum antibiotic with anti-inflammatory, immunomodulatory and neuroprotective properties. It shows promise as …

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Predicting Responders to Minocycline for Depression via Clinical Subgroups

Major depressive disorder (MDD) is a highly prevalent mental illness and leading cause of disability worldwide. While treatments exist, they are far from optimal and up to 30% of patients fail to respond. There is an urgent need to identify factors that may enhance treatment response in MDD. Targeting inflammation has been proposed as a …

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