How a Hidden Proton Channel “TMEM175” Sabotages Brain Cells in Parkinson’s
TL;DR: A 2026 study in PNAS identified acid-triggered opening of the lysosomal proton channel TMEM175 as a pH-sensitive mechanism relevant to Parkinson’s-linked lysosome dysfunction. Key Findings Acidification triggers explosive H+ influx: When pH dropped from neutral (7.4) to acidic (4.7) on the luminal side of TMEM175, inward and outward currents increased continuously, indicating the channel …
