How Blocking DUSP6 Extends Ketamine’s Antidepressant Effect to Months
TL;DR: A 2025 study in Science found that inhibiting DUSP6 extended ketamine-like antidepressant effects in mice by prolonging ERK-linked synaptic plasticity. The problem? The magic doesn’t last. By week two, most patients need another dose, and repeat dosing raises concerns about addiction, dissociation, and the burden of endless clinic visits. Now researchers have found a …
