How FP802 Targets the NMDAR/TRPM4 Death Complex to Reverse Alzheimer’s
TL;DR: A 2026 study in Molecular Psychiatry found that FP802 blocked the NMDAR/TRPM4 death-complex pathway and preserved cognition, synapses, mitochondria, and amyloid-related measures in Alzheimer’s mouse models. Key Findings The NMDAR/TRPM4 death complex forms in Alzheimer’s brains: In 5xFAD mice (a genetic model of the disease), the researchers detected increased interaction between two proteins—the NMDA …
