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Bipolar DisorderJune 9, 2026

Cerebellar Gray Matter Was Lower in Bipolar Than Unipolar Depression

TL;DR: A 2026 study in BMC Psychiatry found that structural MRI of the cerebellum separated first-episode bipolar depression from unipolar depression with 76.3% exploratory model accuracy, mainly because several cerebellar gray-matter regions were smaller in b…

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Artificial Intelligence (AI)May 22, 2026

EHR Machine Learning Predicted Clozapine Initiation in Schizophrenia

TL;DR: A 2026 preprint in medRxiv trained machine-learning models on Danish electronic health records and found that an XGBoost model predicted clozapine initiation within 365 days with an AUROC of 0.81 in patients with schizophrenia or schizoaffective disorde…

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Cerebellar Gray Matter Was Lower in Bipolar Than Unipolar Depression

EHR Machine Learning Predicted Clozapine Initiation in Schizophrenia

The findings. The context. The caveats.