Psilocybin Suppressed SST Interneurons Through 5-HT1A Signaling
TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Findings SST firing decreased: Opto-tagged SST interneurons fell from 5.5 to 3.7 Hz after psilocybin, while saline did not produce …
