Birth DNA Methylation and DMN-Limbic Growth Predicted Age-13 Anxiety in Boys

Birth DNA Methylation and DMN-Limbic Growth Predicted Age-13 Anxiety in Boys

TL;DR: A 2026 Research Square preprint linked DNA methylation (DNAm), an epigenetic mark measured in cord blood at birth, with default mode network-limbic brain development and age-13 anxiety symptoms in boys. Key Findings Birth-to-teen pathway tested: Researchers analyzed 97 children from the GUSTO birth cohort who had cord-blood DNAm, repeated resting-state functional MRI (fMRI) scans, …

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Reward Uncertainty Mapped Mood and Anxiety Signals in Teen fMRI Study

Reward Uncertainty Mapped Mood and Anxiety Signals in Teen fMRI Study

TL;DR: A 2026 study in Neuropsychopharmacology found that reward uncertainty, measured with functional MRI (fMRI), a brain-scan method, engaged different adolescent brain networks during waiting for a possible reward versus learning the outcome, with anxiety and anhedonia tied to different parts of that response. Key Findings 84 adolescents were scanned: The sample included psychotropic-medication-free youth …

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