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CYP2C19 poor metabolizers showed a nominally higher antidepressant remission rate compared to normal metabolizers, but overall genetic variations in CYP2C19 and CYP2D6 were not significantly associated with antidepressant response. Highlights: Higher Remission…
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A study on Tibetans living at high altitudes identified novel risk genes for schizophrenia (SCZ) related to hypoxia, suggesting a unique genetic signature for SCZ in this population. Highlights: Whole-exome sequencing of 47 SCZ cases and 53 controls in Tibetan…
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Obesity has reached epidemic levels globally, with serious health and economic consequences. While lifestyle factors play a key role, genetics also influence a person’s susceptibility to weight gain or difficulty losing weight. An emerging field called pharmac…
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A new large genetics study has discovered new clues into how levels of a protein called apolipoprotein E (ApoE) in the blood may influence a person’s risk of developing Alzheimer’s disease. Key facts: Researchers found 9 new genetic variants that influence Apo…
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