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AlzheimersJune 7, 2026

SPP1 Marked Shared Microglia Programs in Neurodegeneration

TL;DR: A 2026 study in Glia used human single-nucleus RNA sequencing datasets and mouse validation to identify a shared neurodegeneration-linked microglial transcription program, highlighting SPP1 as a disease-associated microglia marker. Key Findings Five dis…

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NeuroscienceOctober 24, 2023

How Many Brain Cells (Neurons) & Glial Cells are in the Human Brain?

For over half a century, neuroscientists operated under the assumption that the human brain contains around 100 billion neurons and over 1 trillion glial cells. This oft-cited “fact” made its way into textbooks and became common knowledge despite a lack of str…

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SPP1 Marked Shared Microglia Programs in Neurodegeneration

How Many Brain Cells (Neurons) & Glial Cells are in the Human Brain?

The findings. The context. The caveats.