lysosomes

How a Hidden Proton Channel “TMEM175” Sabotages Brain Cells in Parkinson’s

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TL;DR: A newly decoded proton channel called TMEM175 lies dormant in lysosomes until acid arrives—then it opens wide and floods the cell with hydrogen ions, disrupting the delicate pH balance linked to Parkinson’s disease and other neurodegeneration. Your cells run a 24/7 recycling system inside tiny acid baths called lysosomes — and when those baths …

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Repurposing Antipsychotics & Antidepressants to Treat Glioblastoma (2024 Study)

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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of Action: The studied antipsychotics and antidepressants induce GBM cell death by disrupting lysosomal function, leading to lysosomal membrane rupture. PTEN Sensitivity: GBMs with intact PTEN …

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