Naltrexone Quieted Threat Signals Without Hurting Reappraisal
TL;DR: A 2026 study in The British Journal of Psychiatry found that a single 50 mg dose of naltrexone reduced distress and shifted threat-related brain activity without blocking people’s ability to reappraise negative images. Key Findings 38 healthy volunteers completed a placebo-controlled crossover: Participants received naltrexone 50 mg and placebo on separate visits, then performed …
