TDP43 Failure Disrupts DNA Repair in ALS and FTD
TL;DR: A 2025 study in Nucleic Acids Research found that TDP43 regulates DNA mismatch-repair transcripts, linking TDP43 dysfunction in ALS and FTD to impaired genome maintenance. Key Findings TDP43 regulates multiple DNA mismatch repair (MMR) genes: When TDP43 is depleted, expression of MLH1, MSH2, MSH3, MSH6, and PMS2 all drop significantly in both dividing cells …
