TL;DR: A 2026 preprint in medRxiv used natural language processing (NLP) on Scottish CT and MRI reports to subtype stroke at scale, linking lobar intracerebral hemorrhage to higher later dementia risk and cortical ischemic stroke to higher early myocardial infarction risk. Key Findings 785,331 head scans: Researchers applied NLP to CT and MRI head-scan reports …
TL;DR: A 2026 population-based matched cohort study in British Journal of Psychiatry found that risperidone use was associated with increased stroke risk, adjusted hazard ratio 1.28, while absolute stroke incidence was especially high in people with prior stroke or cardiovascular disease. Key Findings Matched dementia comparison: The analysis compared stroke risk among risperidone users and …
TL;DR: A 2026 medRxiv preprint linked higher blood inflammatory markers with diffusion MRI signs of altered white-matter microstructure in 457 dementia-free middle-aged and older adults, especially for a combined cytokine score and orientation dispersion index. Key Findings 457 dementia-free participants: The cross-sectional study examined adults with a mean age of 63.82 years and used blood …
TL;DR: A 2026 study in Neurology found that higher autonomic symptom burden in moderate-advanced dementia with Lewy bodies was linked to worse cognitive fluctuations, higher neuropsychiatric burden, and lower caregiver quality of life over time. Key Findings Autonomic burden was measured longitudinally across 189 people with moderate-advanced dementia with Lewy bodies. Higher Autonomic Symptom Checklist …
TL;DR: A 2026 medRxiv preprint found that specific AD8 dementia-screening items, especially judgment, repetition, finances, tool use, and daily memory problems, tracked functional and psychosocial vulnerability in 144 Chinese-speaking older adults. Key Findings Small community sample: The cross-sectional study included 144 Chinese-speaking adults with a mean age of 73.1 years. Three AD8 domains: Exploratory factor …
TL;DR: A 2026 modeling study in Journal of Mathematical Biology found that delayed unfolded protein response (UPR), a cellular stress program that slows protein production, could make toxic prion protein either die out, persist, or oscillate as it spreads through a brain-connectome model. Key Findings The model tracked PrPC and PrPSc: Researchers modeled normal cellular …
TL;DR: A 2026 medRxiv preprint used total-body tau PET in Alzheimer’s disease and found stronger brain-organ network synchrony, a pattern that tracked cognitive impairment through cortical tau burden and MRI markers of glymphatic dysfunction. Key Findings Small imaging cohort: Researchers compared 28 Alzheimer’s disease patients with 23 matched negative controls using positron emission tomography (PET), …
TL;DR: A 2026 Nature Communications paper found that late-stage amyloid beta plaques in APP23 mice recruited CD8 T cells with a type I interferon program, linking Alzheimer-like amyloid pathology to a more adaptive immune response around plaques. Key Findings 21,156 immune cells profiled: The team used single-cell RNA and VDJ sequencing on CD45-positive brain immune …
TL;DR: A 2026 protocol in PLOS One describes a 90-person pilot randomized controlled trial that will test whether virtual reality mindfulness can reduce depression, anxiety, stress, and caregiver burden in family caregivers of people with dementia. Key Findings 90-caregiver pilot: The planned sample includes 90 caregivers of community-dwelling people with dementia in Hong Kong. Three …
TL;DR: A 2026 mouse study in Proceedings of the National Academy of Sciences found that deleting or inhibiting PTP1B improved memory behavior, reduced amyloid-beta burden, and pushed microglia toward an amyloid-clearing state. Key Findings Memory behavior improved: APP/PS1 mice lacking PTP1B performed better in novel object recognition and Morris water maze tests; the PTP1B inhibitor …
