Focused Ultrasound Reprogrammed Microglia in Alzheimer’s Rats
TL;DR: A 2026 bioRxiv preprint found that repeated focused ultrasound changed blood-brain-barrier and microglial biology in Alzheimer’s rats without clearly improving pathology on its own. Key Findings Day 7 after 4 weekly sessions: Aβ42 and pTau231 went the wrong way: Aggregated Aβ42 rose (p = 0.0059), pTau231 rose (p = 0.0009). Repeated barrier opening alone …
