A series of studies suggest that repeated low doses of d-amphetamine can lead to a progressively greater behavioral response in some people. This phenomenon, known as “behavioral sensitization,” has been observed in animal models and hypothesized to contribute to addiction in humans. However, few controlled human studies have directly tested this idea. A new double-blind, …
Amphetamine is well known for its ability to increase dopamine levels in the brain. But new research suggests the psychostimulant drug may also directly alter dopamine 2 receptors, with implications for behavioral effects and physiological changes seen after chronic amphetamine use. Key facts: In cells expressing the dopamine transporter, prolonged amphetamine exposure decreased dopamine 2 …
Smoking remains a major public health issue. Nicotine, the primary addictive component of tobacco, may enhance cognition but also drives continued use. Understanding nicotine’s effects on the brain is key for developing better interventions. Key facts: Nicotine enhances functions like attention, motor skills, and memory but mechanisms remain unclear. Genetic variations predict responses to nicotine’s …
Flakka, the latest dangerous designer drug, has rapidly spread across the United States and beyond. This synthetic cathinone has powerful stimulant effects leading to delirium, aggression, dangerous health issues, and even death. What is Flakka and Why Is It So Troubling? Flakka, commonly referred to as gravel or bath salts, is the street name for …
Attention-deficit/hyperactivity disorder (ADHD), long thought of as a childhood condition, is increasingly recognized as a disorder that can persist into adulthood. Up to 60% of children with ADHD continue to experience symptoms as adults. Yet treatment options specifically tested and approved for adult ADHD remain limited. A new study published this month in the Journal …
Major depressive disorder affects over 17 million American adults each year. For up to 30% of these patients, standard antidepressant medications fail to provide adequate symptom relief – a condition known as treatment-resistant depression (TRD). Now, new research suggests amphetamine-based stimulants like Adderall may be an effective augmentation strategy for TRD when other therapies have …
A new study reveals that the recreational drugs MDMA (also known as ecstasy or molly) and methamphetamine can increase feelings of connection and closeness with strangers during conversations. Key Facts: MDMA and methamphetamine were tested on separate groups of healthy volunteers in double-blind, placebo-controlled studies. After taking MDMA or methamphetamine, participants had more enjoyable and …
