CB1 Receptor Autophagy Did Not Explain p62 Mouse Obesity Phenotype
TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knockout mice. Key Findings CB1R accumulated up to 10-fold: Blocking autophagic flux with Bafilomycin A1 in …
