TL;DR: A 2026 systematic review in PLOS One found that ketogenic diet therapies were linked to more 50% seizure reductions in drug-resistant epilepsy, with clearer evidence in children and more uncertainty for near-complete seizure control, side effects, adherence, and quality of life. Key Findings 17 randomized trials were included: The review screened 1,193 records after …
TL;DR: A 2026 randomized trial in Journal of the International Society of Sports Nutrition found that 12 weeks of combined interval resistance and aerobic training increased Maresin-1, an inflammation-resolving lipid mediator, in men with obesity, with the largest insulin-resistance improvement when training was paired with 200 mg/day fisetin. Key Findings 44 men completed the trial: …
TL;DR: A 2026 randomized follow-up study in Maternal & Child Nutrition found no overall hair-cortisol difference at ages 9-11 after early-life small-quantity lipid-based nutrient supplementation, but children whose mothers had 0-5 years of schooling had lower cortisol if they received SQ-LNS. Key Findings No overall cortisol shift: Usable hair cortisol data from 680 children showed …
TL;DR: A 2026 preprint in medRxiv linked a higher 24-hour urinary sodium-to-potassium ratio with deep white matter lesions on brain MRI in older Japanese adults, with the association appearing to depend more on lower potassium excretion than on sodium alone. Key Findings Urine balance was matched to MRI lesions: The analysis included 296 adults from …
TL;DR: A 2026 cohort study in PLOS One found that higher fasting plasma vitamin C levels were independently associated with larger MRI-measured gray matter and stronger default mode network (DMN) structural connectivity in 2,044 older adults, but the cross-sectional design cannot show that vitamin C caused the brain differences. Key Findings Large MRI cohort: The …
TL;DR: A 2026 study in Nature Metabolism identified brain hyperglycosylation as a metabolic driver of Alzheimer disease in human tissue and mouse models, while glucosamine exposure was linked to worse outcomes in Alzheimer-related dementia records. Key Findings Human AD brains showed excess glycans: Spatial glycomics found elevated N-glycan abundance in Alzheimer frontal cortex samples compared …
TL;DR: A 2026 systematic review and meta-analysis in International Journal of Obesity found that glucagon-like peptide-1 receptor agonists, metabolic drugs that extend a satiety and glucose-control hormone pathway, reduced body weight mainly through fat loss while lean-mass reductions were generally modest. Key Findings 36 studies reviewed: Researchers included 36 studies in the qualitative review and …
TL;DR: A 2026 mouse study in Nature Communications found that early-life high-fat/high-sugar diet exposure left sex-specific adult feeding and hypothalamic changes, and microbiota-targeted interventions partly restored those effects. Key Findings Early-life HFHS exposure: Mice exposed to a high-fat/high-sugar diet only in early life showed persistent adult feeding changes despite normalized body weight. Sex-specific vulnerability: Females …
TL;DR: A 2025 human proteomics study in Molecular Metabolism found that about 10 days of medically supervised water-only fasting caused weight loss and lower circulating amyloid beta proteins, but also increased inflammatory and platelet-activation markers. Key Findings 20 volunteers: The main cohort included 20 middle-aged adults with mean age 52.2 years and mean BMI 28.8 …
TL;DR: A 2026 mouse study in Neuron found that exercise activates ventromedial hypothalamic SF1 neurons, and that this brain response is required for normal endurance gains after training. Key Findings VMH SF1 neurons: Exercise increased activity-linked Bdnf expression in steroidogenic factor-1 neurons in the ventromedial hypothalamus. Training plasticity: Repeated exercise increased both intrinsic excitability and …
