ADNI

MRI Brain Pattern Index Predicted Alzheimer’s Conversion Risk

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MRI Brain Pattern Index Predicted Alzheimer's Conversion Risk

TL;DR: A 2026 Molecular Psychiatry study tested Regional Vulnerability Index for Alzheimer’s disease (RVI-AD), a structural-MRI score of how closely a person’s brain pattern resembles amyloid-positive Alzheimer’s disease, and found that higher RVI-AD predicted conversion from mild cognitive impairment to dementia most strongly in the first 3 years. Key Findings 571-person reference map: Researchers built …

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SimulAD Modeled Amyloid Clearance in Alzheimer’s Trials

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SimulAD Modeled Amyloid Clearance in Alzheimer's Trials

TL;DR: A 2026 medRxiv preprint tested SimulAD, an Alzheimer’s disease progression simulator, and reported that it reproduced mean amyloid-clearance results within 5% error across six major phase III anti-amyloid trials while also separating positive trials from null trials in retrospective power analyses. Key Findings Six phase III trials: Researchers retrospectively simulated TRAILBLAZER-ALZ2, CLARITY AD, EMERGE, …

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