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TL;DR: A 2026 Nature Communications paper introduced CAptVE, a fluorescent aptamer method that labels molecular features in mouse brain tissue while preserving ultrastructure for electron-microscopy connectomics. Key Findings Detergent-free labeling: CAptVE us…
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Connectome-seq Turned Synapses Into Barcodes TL;DR: Connectome-seq is a 2026 Nature Methods platform that maps brain wiring by combining engineered synaptic proteins, RNA barcodes, single-nucleus sequencing, and single-synaptosome sequencing. In a mouse pontoc…
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Researchers have for the first time reconstructed all neurons and their connections in the brain of a fruit fly larva, revealing fundamental principles of brain organization. The study provides an important scaffold for understanding the neural basis of behavi…
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