Ketamine’s Long-Lasting Antidepressant Effects via “Trapping” in NMDA Receptors & LHb

Researchers uncover a surprising molecular mechanism that explains ketamine’s exceptionally long-lasting antidepressant effects. Key Facts: Ketamine’s antidepressant effects last for days after its concentration drops to low, ineffective levels only an hour after administration. This contrasts starkly with ketamine’s short 13-minute half-life in the body. Ketamine continues blocking NMDA receptors and suppressing activity in the …

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Deep Brain Stimulation for Depression: Determining Optimal Targets & Protocols

Deep brain stimulation (DBS) is an emerging experimental therapy that has shown promise in treating patients with severe, treatment-resistant depression (TRD). Early research indicates DBS may help patients who have failed to respond to medications, psychotherapy, and other interventions. Key facts: DBS involves surgically implanting electrodes in specific brain regions to deliver mild electrical stimulation. …

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