Ketamine’s Antidepressant Pathway Reverse-Engineered: Low-Dose Three-Drug Combination Reproduced Effect in Mice
TL;DR: A 2026 mouse study in Cell traced ketamine’s rapid antidepressant-like effect to mu-opioid receptors on somatostatin-positive interneurons in the medial prefrontal cortex. Low-dose multi-GPCR targeting reproduced ketamine-like effects in mice, but the e…
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