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PV interneurons

MedicalJune 5, 2026

Orbitofrontal PV Interneurons Reduced Social Behavior via DMN Connectivity

TL;DR: A 2026 mouse study in Communications Biology found that activating parvalbumin (PV) interneurons, inhibitory nerve cells in the orbitofrontal cortex, reduced default mode network connectivity and decreased normal social approach and sniffing behavior. K…

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Drugs & MedicationsMay 16, 2026

Psilocybin Suppressed SST Interneurons Through 5-HT1A Signaling

TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Finding…

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Orbitofrontal PV Interneurons Reduced Social Behavior via DMN Connectivity

Psilocybin Suppressed SST Interneurons Through 5-HT1A Signaling

The findings. The context. The caveats.