TL;DR: A 2026 preprint in medRxiv reported that serum myelin oligodendrocyte glycoprotein (MOG) protein was higher in multiple sclerosis than controls and higher during clinical relapse than remission. Key Findings 20.5 pg/ml higher: Serum MOG protein was higher in MS than healthy donors by a mean difference of 20.5 pg/ml. 27.5 pg/ml higher: MS samples …
TL;DR: A 2026 study in PNAS from Oregon Health & Science University and Anhui University used optogenetics in mice to map a specific serotonin-producing brain circuit that runs straight to the auditory system, showed that activating this circuit produced tinnitus-like behavior, and traced a likely mechanism for why some patients on SSRI antidepressants report worsened …
TL;DR: A 2026 preprint in medRxiv reported that SenseCheQ, a home quantitative sensory testing device, produced reliable vibration and temperature-threshold measurements in 30 healthy adults and tracked early sensory changes in 3 breast cancer patients receiving neurotoxic chemotherapy. Key Findings 30-person home study: Healthy adults completed one familiarization session and three self-administered home sessions using …
TL;DR: A 2026 population-based matched cohort study in British Journal of Psychiatry found that risperidone use was associated with increased stroke risk, adjusted hazard ratio 1.28, while absolute stroke incidence was especially high in people with prior stroke or cardiovascular disease. Key Findings Matched dementia comparison: The analysis compared stroke risk among risperidone users and …
TL;DR: A 2026 randomized pilot trial in European Journal of Psychotraumatology found no overall PTSD advantage when refugee-focused emotion-regulation skills training was added before narrative exposure therapy, but refugees living with high visa or family insecurity showed preliminary self-report gains from the skills-first approach. Key Findings 71 adult refugees were randomized: Participants met DSM-5 criteria …
TL;DR: A 2026 HomePAP secondary analysis in Journal of Clinical Sleep Medicine found that higher PAP mask leak predicted lower obstructive sleep apnea treatment adherence, but a new Real Leak measure, unintentional leak after subtracting expected mask leak, did not outperform conventional Average Leak. Key Findings HomePAP sample size: PAP data were available for 139 …
TL;DR: A 2026 birth cohort study in Environment & Health linked low-level prenatal lead exposure to lower infant Ages and Stages Questionnaire (ASQ-3) developmental scores, with FAM50B/PTCHD3 DNA methylation markers explaining part of the association. Key Findings Lead was the clearest metal finding: Among 21 detectable cord-blood metals, lead showed a consistent negative association with …
TL;DR: A 2026 study in Journal of Pain Research described 3 adults with type I complex regional pain syndrome (CRPS), a severe neuropathic pain condition with sensory, autonomic, motor, and skin changes, whose pain scores improved after pregabalin and who were then able to participate more fully in rehabilitation. Key Findings Case-series evidence: Researchers reported …
TL;DR: A 2026 study in Journal of Pain Research found that spinal cord stimulation and dorsal root entry zone lesioning reduced pain for selected patients with refractory postherpetic neuralgia, but the evidence came from a 10-patient single-center series. Key Findings 10 refractory PHN patients: The retrospective series included 6 men and 4 women treated between …
TL;DR: A 2026 medRxiv preprint found that nonverbal Theory of Mind (ToM), the ability to infer another person’s beliefs or perspective, varied in 44 adults with post-stroke aphasia and was more closely tied to vascular brain-health markers than to aphasia severity. Key Findings Study group: 44 adults with aphasia after mostly left-hemisphere stroke completed 2 …
