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TL;DR: A 2026 study in Glia used human single-nucleus RNA sequencing datasets and mouse validation to identify a shared neurodegeneration-linked microglial transcription program, highlighting SPP1 as a disease-associated microglia marker. Key Findings Five dis…
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Connectome-seq Turned Synapses Into Barcodes TL;DR: Connectome-seq is a 2026 Nature Methods platform that maps brain wiring by combining engineered synaptic proteins, RNA barcodes, single-nucleus sequencing, and single-synaptosome sequencing. In a mouse pontoc…
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Immature Neurons Linked to Alzheimer’s Resilience TL;DR: A 2026 Cell Stem Cell study used single-nucleus RNA sequencing of aged human hippocampus tissue and found rare immature neurons in healthy, Alzheimer’s, and dementia-resilient brains. The important signa…
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