Amitriptyline Pollution Disrupted Male Guppy Spatial Learning

Amitriptyline Pollution Disrupted Male Guppy Spatial Learning

TL;DR: A 2026 study in Environmental Science & Technology found that male guppies exposed for 11 days to environmentally relevant amitriptyline, a tricyclic antidepressant detected in waterways, made more spatial-learning errors in a maze while females were largely unaffected. Key Findings 170-fish learning test: Researchers tested wild-caught male and female guppies across 12 maze trials …

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Peptide PHDP5 May Reverse Cognitive Impairment in Alzheimers Disease (2024 Research)

TLDR: Researchers demonstrated that intranasal administration of the peptide FITC-PHDP5-CPP reverses early cognitive impairment in Alzheimer’s disease (AD) model mice, showing potential as a treatment for AD-associated cognitive decline. Highlights: PHDP5, derived from the pleckstrin homology domain of dynamin 1, inhibits the interaction between dynamin and microtubules, rescuing synaptic dysfunction caused by tau accumulation. The …

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