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basal ganglia

MedicalJune 20, 2026

Brain Iron Deficiency Sensitized a Dopamine-Opioid Restless Legs Pathway

TL;DR: A 2026 mouse study in Neuropsychopharmacology found that brain iron deficiency made an opioid-responsive striatal pathway unusually sensitive to D1 dopamine receptor stimulation, pointing to a possible circuit mechanism for restless legs syndrome and op…

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Drugs & MedicationsJune 12, 2026

Putamen-Focused tTIS Lowered Parkinson’s Motor Scores

TL;DR: A 2026 preprint posted to medRxiv found that intermittent theta-burst transcranial temporal interference stimulation (iTBS-tTIS), a noninvasive electrical method aimed at the right putamen, lowered left-sided Parkinson’s motor scores during stimulation…

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Brain Iron Deficiency Sensitized a Dopamine-Opioid Restless Legs Pathway

Putamen-Focused tTIS Lowered Parkinson’s Motor Scores

The findings. The context. The caveats.