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TL;DR: A 2026 study in Signal Transduction and Targeted Therapy engineered a modified inhibitory DREADD receptor called GRANPA so the over-the-counter antihistamine diphenhydramine could switch off targeted brain circuits and reduce seizure activity in mouse m…
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TL;DR: A 2026 rat study in Brain Structure and Function found that ventral pallidum activity supports juvenile social play, while activating inhibitory nucleus accumbens inputs to the ventral pallidum reduced play behavior in both male and female rats. Key Fin…
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TL;DR: A 2026 mouse study in Communications Biology found that activating parvalbumin (PV) interneurons, inhibitory nerve cells in the orbitofrontal cortex, reduced default mode network connectivity and decreased normal social approach and sniffing behavior. K…
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TL;DR: A 2026 rat study in Neuropsychopharmacology found that chemogenetically inhibiting a prelimbic cortex to nucleus accumbens core pathway blocked cue-triggered cocaine seeking after cocaine alone, but did not block relapse-like behavior after sequential c…
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