metabolomics

EMBER-MDD Will Test Multi-Omic Biomarkers for Esketamine Response

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EMBER-MDD Will Test Multi-Omic Biomarkers for Esketamine Response

TL;DR: A 2026 methodology paper in European Archives of Psychiatry and Clinical Neuroscience describes EMBER-MDD, a research-only multi-omic study designed to find treatment-resistance and esketamine-response biomarkers in about 420 adults with major depressive disorder. Key Findings About 420 adults: EMBER-MDD will analyze biomaterials from approximately 420 adults with major depressive disorder. 210 versus 210 design: …

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Indoleacrylic Acid Linked to PFO-Migraine Metabolomics

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Indoleacrylic Acid Linked to PFO-Migraine Metabolomics

TL;DR: A 2026 study in iScience found that migraine patients with patent foramen ovale had altered plasma metabolic profiles, with lower indoleacrylic acid and an IA-plus-hs-CRP marker pair showing exploratory discrimination in a validation cohort. Key Findings 30 discovery patients: Untargeted metabolomics compared 30 migraine patients with patent foramen ovale against 17 matched controls. 4,858 …

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Metabolic Biomarkers & Future Depressive Symptoms: Is There a Link?

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A new study examined whether metabolic biomarkers assessed through a high-throughput method are associated with future depressive symptoms. The results suggest the metabolites may not play a direct role in depression development. Key Facts: Researchers investigated associations between 121 metabolic measures and depressive symptoms at 7-year follow-up. Some metabolites showed tendencies for links with more …

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