TL;DR: A 2026 protocol in JMIR Research Protocols describes EXCEL-PD, a randomized trial testing whether 26 weeks of virtually supervised home endurance and resistance exercise is feasible, safe, and biologically informative for people with Parkinson disease. Key Findings Home trial design: EXCEL-PD randomizes 31 planned participants with Parkinson disease to home-based exercise or waitlist usual …
TL;DR: A 2026 retrospective analysis posted to medRxiv linked diclofenac and naproxen use in the NACC cohort to lower dementia and Alzheimer disease prevalence, while diclofenac use was also associated with slower Montreal Cognitive Assessment (MoCA) cognitive-screening decline. Key Findings NACC cohort: The analysis used 47,165 National Alzheimer’s Coordinating Center participants with data collected from …
TL;DR: A 2026 protocol posted to medRxiv describes a nationwide Japan survey designed to measure how dementia specialists handle anti-amyloid antibody therapy, biomarker testing, MRI safety monitoring, service capacity, and patient-choice tradeoffs. Key Findings Nationwide specialist survey: The protocol targets board-certified dementia specialists in Japan, especially physicians trained for anti-amyloid antibody therapy. June 2026 data …
TL;DR: A 2026 mouse study in Nature found that age-related gut microbiome changes impaired vagal gut-brain signaling and hippocampal memory encoding, while several interventions restored memory performance in aged or microbiome-aged mice. Key Findings Aged microbiome transfer impaired memory: Young mice exposed to aged gut microbes showed worse novel object recognition and Barnes maze performance …
TL;DR: A 2026 study in Nature recorded human hippocampal neurons during propofol anesthesia and found preserved oddball-tone discrimination, short-term plasticity, and language-related semantic coding during surgical loss of consciousness. Key Findings 7 surgical patients: Researchers recorded hippocampal activity with Neuropixels probes during general anesthesia in patients undergoing epilepsy surgery. 172 tone-responsive units: The tone task …
TL;DR: A 2026 study in Open Medicine used network pharmacology, Alzheimer’s disease transcriptomic datasets, machine learning, Mendelian randomization, and molecular docking to link 6PPD-quinone, a tire-wear chemical transformation product, with inflammation, oxidative-stress, kinase-signaling, and synaptic pathways relevant to Alzheimer’s disease. Key Findings 92 overlapping targets: Database mining found 92 molecular targets shared between 6PPD-quinone and …
TL;DR: A 2026 cohort study in PLOS One found that higher fasting plasma vitamin C levels were independently associated with larger MRI-measured gray matter and stronger default mode network (DMN) structural connectivity in 2,044 older adults, but the cross-sectional design cannot show that vitamin C caused the brain differences. Key Findings Large MRI cohort: The …
TL;DR: A 2026 randomized trial in International Journal of Clinical and Health Psychology found that older adults who knowingly took placebo pills for 3 weeks reported lower stress and performed better on Digit Span than controls. Key Findings Aging trial context: The trial randomized 90 healthy community-dwelling adults in Milan, ages 65 to 90, into …
TL;DR: A 2026 feasibility study in the Journal of Activity, Sedentary and Sleep Behaviors found that pregnant participants could use a research-grade accelerometer plus text-message sleep diaries across much of pregnancy, although third-trimester wear declined. Key Findings 10 pregnant participants: The pilot recruited Kaiser Permanente Northern California members at 10 weeks’ gestation and followed them …
TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health linked composite inflammatory biomarkers during pregnancy and postpartum with postpartum anxiety symptoms, but the strongest associations ran in the unexpected direction of lower anxiety risk at higher biomarker levels. Key Findings 14,419 postpartum women were screened: Researchers calculated inflammatory biomarkers during the 2nd trimester, …
