Pharmacogenetics

Treatment-Resistant Depression Affected 34% in Pakistan DIVERGE Study

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Treatment-Resistant Depression Affected 34% in Pakistan DIVERGE Study

TL;DR: A 2026 preprint in medRxiv found that treatment-resistant depression affected 34% of medication-exposed major-depression patients in Pakistan’s DIVERGE study, with social support and CYP2C19 metabolizer status standing out as locally important treatment-response markers. Key Findings 3,677 eligible patients: The treatment-resistance analysis included adults with major depressive disorder who had medication exposure and enough adherence …

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New Research Upends Long-Standing Theory on How Memories Form

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Groundbreaking new research challenges decades of accepted neuroscience dogma on how memories are formed in the brain. The study provides strong evidence that the induction of long-term potentiation (LTP), widely believed to be the cellular mechanism underlying memory formation, relies on structural changes in neurons rather than enzymatic activity as long thought. Key Takeaways: LTP …

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