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DepressionMay 22, 2026

TRD Brain Networks Decoupled Structure From Function

TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depressio…

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DepressionSeptember 19, 2023

Advances in Treatment-Resistant Depression: Causes, Symptoms, Interventions

Major depressive disorder (depression) is very common. It causes a lot of suffering and disability around the world. The good news is many people get better with medication, psychotherapy (talk therapy), or both. But for some people, depression just won’t go a…

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TRD Brain Networks Decoupled Structure From Function

Advances in Treatment-Resistant Depression: Causes, Symptoms, Interventions

The findings. The context. The caveats.