Antipsychotics

Repurposing Antipsychotics & Antidepressants to Treat Glioblastoma (2024 Study)

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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of Action: The studied antipsychotics and antidepressants induce GBM cell death by disrupting lysosomal function, leading to lysosomal membrane rupture. PTEN Sensitivity: GBMs with intact PTEN …

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Case Report: 10,000 mg Clozapine Overdose in 71-Year-Old Female (2024)

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TLDR: This case study reports the highest recorded nonfatal clozapine overdose (10,000 mg) in an elderly patient, causing significant fluctuations in blood concentration levels following treatment. Highlights: A 71-year-old female ingested 10,000 mg of clozapine, significantly above typical overdose levels, leading to an initial blood concentration of 5200 μg/L. Despite initial treatment, blood clozapine levels …

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Antipsychotics & Gray Matter Loss in Chronic Schizophrenia

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Schizophrenia is a severe mental illness characterized by hallucinations, delusions, disorganized thinking and behavior. While antipsychotic medications can help manage symptoms, their long-term effects on brain structure are not fully understood. A new study provides important insights into how long-term antipsychotic treatment may impact gray matter in chronic schizophrenia. Key Facts: Both treated and untreated …

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Antipsychotics & High Prolactin Levels: Which Drugs Cause Hyperprolactinemia Most Often?

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Antipsychotic medications are commonly used to treat psychotic disorders like schizophrenia and bipolar disorder. However, these drugs often cause side effects like elevated prolactin levels, which can negatively impact long-term health. A new study analyzed medical records to compare prolactin levels between patients taking different antipsychotics. It found risperidone and amisulpride caused the greatest prolactin …

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Top Drugs & Medications that Cause Weight Gain: Worst Offending Pharmaceuticals (2012-2021)

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A new study published in Pharmazie takes a close look at adverse event reports related to drug-induced weight gain submitted to the FDA over the past 10 years. The retrospective analysis provides insight into the drugs most commonly associated with weight gain side effects. Key findings include: From 2012 to 2021, 137,370 reports of drug-induced …

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