TL;DR: A 2026 mouse study in Translational Psychiatry reported that six days of adolescent THC exposure reduced Reelin-positive cell density in the female prefrontal cortex and cortical thickness across sexes. Prenatal immune activation did not consistently magnify the effects, and the short-term animal experiment does not show that cannabis causes schizophrenia in people. Key Findings …
TL;DR: A 2026 medRxiv preprint introduced a 68-component NeuroMark template for single photon emission computed tomography (SPECT), a brain blood-flow imaging method, and found schizophrenia-related differences in cerebellar, subcortical, higher-cognition, visual, and triple-network perfusion patterns. Key Findings Template build: Researchers used blind independent component analysis on two large SPECT datasets of 5,001 and 5,000 scans …
TL;DR: A 2026 systematic review and meta-analysis in International Journal of Molecular Sciences found no significant global gut-microbiome alpha-diversity difference in schizophrenia, but reported recurring community-composition and taxonomic shifts. Key Findings 48 studies: The review included 48 human observational studies published between 2017 and 2025. 14 meta-analyzed studies: Only 14 studies provided enough data for …
TL;DR: A 2026 preprint on medRxiv used multisite MRI data from 3,958 people with schizophrenia and 5,489 controls to map cortical network disruptions and identify two robust brain-structure subtypes. Key Findings 9,447 MRI participants: The analysis included 3,958 individuals with schizophrenia and 5,489 neurotypical controls from 40 centers. Gradient alterations: Schizophrenia was linked with widespread …
TL;DR: A 2026 systematic review and meta-analysis in Lupus found that psychosis affected about 4.5% of adults with systemic lupus erythematosus (SLE), was more common in neuropsychiatric SLE, and tracked most strongly with active immune disease markers rather than serving as a stand-alone psychiatric label. Key Findings Sixty-five studies were included: The review covered 31,495 …
TL;DR: A 2026 study in European Archives of Psychiatry and Clinical Neuroscience found that more than half of 184 young adults entering an early-psychosis supported employment and education trial were not in work, school, or training, even though nearly all had finished at least lower- or upper-secondary schooling. Key Findings The SEEearly cohort included 184 …
TL;DR: A 2026 systematic review in Molecular Psychiatry found that microglia-related findings across major depression, bipolar disorder, and schizophrenia were better explained by biological subgroups than by one uniform diagnosis-by-diagnosis inflammation pattern. Key Findings Three evidence streams: The review integrated human translocator protein positron emission tomography (TSPO-PET) imaging, cerebrospinal fluid kynurenine-pathway metabolites, and postmortem microglial …
TL;DR: A 2026 study in Psychiatry and Clinical Neurosciences Reports described a treatment-resistant residual-phase schizophrenia case in which valproate helped agitation but caused hypoglycemia and pancytopenia, while lithium augmentation was followed by lower hostility and excitement scores. Key Findings 49-year-old patient: The case involved a Japanese woman with chronic treatment-resistant schizophrenia and persistent agitation, aggression, …
TL;DR: A 2026 claims analysis in Exploratory Research in Clinical and Social Pharmacy found that FDA-declared first-generation antipsychotic shortages were followed by medication switching in 9.13% of included patients with psychotic spectrum disorders, with especially high switching after thiothixene, trifluoperazine, and molindone shortages. Key Findings The claims cohort was large: 95,968 patients had a psychotic …
TL;DR: A 2026 sham-controlled study in BMC Psychiatry found that one 15-minute session of 1.5 mA anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex did not improve visuospatial or verbal working memory in clinically stable schizophrenia patients. Key Findings 27 schizophrenia patients: The final analysis included 14 men and 13 women …
