Cocaine use can lead to significant structural changes and accelerated aging of the brain, according to a new study. Key findings include: Cocaine users showed widespread gray matter loss in areas involved in emotions, language, cognition and decision-making. Cocaine users had “older” looking brains, with brain-predicted age 2.5 years higher than their real age. Brain …
Classical psychedelics like LSD and psilocybin have recently re-entered mainstream discussions surrounding mental health. Small clinical trials have shown promising results for their therapeutic potential in treating conditions like depression, anxiety and addiction. However, beyond their clinical utility, many questions remain regarding the impact of these substances on psychological aspects like personality and belief systems. …
Brain serotonin is crucially involved in regulating mood, social behavior, and physical health. While medications that alter serotonin levels have revolutionized psychiatry, non-drug approaches may provide safer, sustainable ways to optimize serotonin and promote wellbeing. Key Facts: Brain serotonin influences mood, sociability, and health in animals and humans. Higher serotonin is linked to positive mood, …
Researchers have uncovered new evidence that a traditional Chinese herbal medicine may be a safe, effective option for treating depression. The formula, known as Chaihu-jia-Longgu-Muli-tang (CLM) also phrased “Chai Hu Jia Long Gu Mu Li Tang,” outperformed standard antidepressants in clinical trials and appears to work via multiple mechanisms in the brain. Key findings: In …
Suicide is a major global public health problem, accounting for over 800,000 deaths worldwide each year. Lithium, a mood stabilizing medication, has been proposed as a novel population-level suicide prevention strategy through supplementation of trace doses into the public drinking water supply. This controversial idea has sparked much debate around its ethics, risks, benefits and …
Borderline personality disorder (BPD) is a common and debilitating mental health condition, yet medication options remain limited according to a new systematic review published in CNS Drugs. The study found minimal evidence supporting the benefits of medication for BPD beyond some improvement in individual symptoms. No drugs have been approved for BPD and there is …
Mood disorders like major depression and bipolar disorder affect millions worldwide. Existing treatments often fall short, highlighting the need for better options. An emerging possibility is anti-inflammatory drugs like celecoxib that may target the immune system abnormalities linked to these conditions. A new comprehensive review suggests celecoxib holds promise as an add-on treatment for major …
A new network meta-analysis published in Frontiers in Pharmacology provides important insights into the relative efficacy and safety of monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) for migraine prevention. This comprehensive analysis compares four CGRP monoclonal antibodies – eptinezumab, erenumab, fremanezumab, and galcanezumab – and sheds light on which ones are most effective for reducing …
Attention-deficit/hyperactivity disorder (ADHD), long thought of as a childhood condition, is increasingly recognized as a disorder that can persist into adulthood. Up to 60% of children with ADHD continue to experience symptoms as adults. Yet treatment options specifically tested and approved for adult ADHD remain limited. A new study published this month in the Journal …
Brain zaps are brief, electric shock-like sensations felt in the brain that can occur when decreasing or stopping dosage of certain antidepressants. Though poorly understood, new research is shedding light on this perplexing phenomenon. Key Facts: Brain zaps are a recently acknowledged potential side effect of discontinuing certain antidepressants like SSRIs and SNRIs. They feel …
