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Depression affects over 300 million people globally. Current antidepressants have limited efficacy and slow onset of action. New research shows promise for compounds targeting metabotropic glutamate receptors 2 and 3 (mGluR2/3) as fast-acting antidepressants w…
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New research reveals that increased inflammation, indicated by higher levels of a protein called VCAM-1, is associated with decreased gray matter and altered brain connectivity in patients with major depressive disorder (MDD). These brain changes also correlat…
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A new study examined whether metabolic biomarkers assessed through a high-throughput method are associated with future depressive symptoms. The results suggest the metabolites may not play a direct role in depression development. Key Facts: Researchers investi…
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A new meta-analysis found that continuous theta burst stimulation (cTBS), a novel form of brain stimulation therapy, does not appear to be more effective than sham (placebo) stimulation for treating symptoms of major depression. Key Facts: cTBS is a type of re…
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Eating foods rich in certain flavonoids may help lower the risk of experiencing depressive symptoms, suggests new research based on U.S. national health data. Key facts: Higher intakes of anthocyanidins, flavanones, flavones, and isoflavones were associated wi…
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An innovative study aims to assess the feasibility of patients self-managing transcranial direct current stimulation (tDCS) therapy for depression at home. This digitally-supported model could greatly expand access if proven safe, reliable and effective. Key F…
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The European Medicines Agency (EMA) has updated its guidance on clinical trials for new depression treatments, with the goals of harmonizing standards across the EU and facilitating development of improved therapies. Key Facts: Depression is a highly disabling…
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Electroretinography, a non-invasive retinal scanning technique, shows some promise for detecting suicidal behaviors based on changes in retinal cell signals. However, large scale studies are needed to determine its reliability. Key Facts: Electroretinography (…
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A new study conducted in rural South India has found that people whose parents are blood relatives (consanguineous marriage) have an increased risk of developing schizophrenia compared to the general population. Key Facts: Researchers recruited 120 patients wi…
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Kava kava, an herbal supplement made from the root of Piper methysticum, has gained popularity as an alternative treatment for anxiety and insomnia. A recent systematic review and meta-analysis re-examined kava kava’s effectiveness and safety for anxiety disor…
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