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Those with personality disorders face an elevated risk of suicidal thoughts, attempts, and deaths. Factors like childhood trauma and substance use issues may partially explain this vulnerability. While treatments like dialectical behavior therapy show promise…
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Antidepressant use has risen steadily for 30 years. Over 10% of adults in England now take them long-term, but evidence suggests up to half lack clear medical justification to continue. Patients and doctors are reluctant to stop treatment due to fears of relap…
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Insomnia is a common sleep disorder affecting up to 15% of adults. While sedative medications are often prescribed, their long-term use can lead to dependence. As an alternative, antidepressants are widely used in clinical practice despite limited evidence sup…
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Current antidepressants can take weeks to improve symptoms of depression. New research explores reasons for this delay and provides clues to develop more rapid-acting drugs. Key Facts: Most antidepressants increase brain serotonin and norepinephrine, but their…
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Minor or subthreshold depression causes significant suffering and impairment, despite falling short of a major depression diagnosis. Effective early treatment is crucial to alleviate symptoms, improve functioning, and prevent progression to major depression. B…
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Depression often comes with significant sleep disturbances that can persist even after other symptoms improve. Choosing an antidepressant that alleviates sleep problems may improve outcomes. Key Facts: Sleep complaints like insomnia occur in 60-90% of depressi…
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A new Mayo Clinic study is the first to clinically investigate whether antidepressants that impact mitochondrial function differently are associated with varying rates of treatment-emergent mania in bipolar disorder. The study found that antidepressants that i…
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A large review of research found that talk therapy works about as well as antidepressant medications for treating depression. The study also looked at other non-drug options, like exercise. While benefits were similar across treatments, side effects differed.…
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The NLRP3 inflammasome is increasingly being recognized as a mediator between inflammation and depression. Targeting this molecular complex shows promise for developing new antidepressant therapies. Key Facts: The NLRP3 inflammasome is made up of NLRP3, ASC, a…
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Depression is one of the most common mental health issues, affecting over 320 million people globally. Research shows that exercise may be an effective treatment option for many battling this disabling condition. Key Facts: Exercise has comparable antidepressa…
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