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Opioid System Activation is Required for Ketamine’s Antidepressant Effects Ketamine is fast—a single subanesthetic infusion reduces severe depression symptoms within hours, not weeks. But the mechanism remains incompletely understood. For nearly two decades, r…
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Drug-induced musical hallucinations occur across various medical conditions, with antidepressants, opioids, and other medications as common triggers, potentially arising from neurotransmitter imbalances; treatment often involves modifying or discontinuing the…
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Ketamine significantly reduces suicidal ideation in depressed patients, with rapid effects observed within the first day of treatment. Highlights: Rapid Reduction: Ketamine shows a significant reduction in suicidal ideation within the first day of treatment (R…
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Repurposing general anesthetic drugs like ketamine for the treatment of major depression represents a significant medical advancement – showcasing rapid and sustained antidepressant effects. Highlights: Rapid Antidepressant Effects: Ketamine, nitrous oxide, pr…
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A study examined the effects of ketamine on sleep arousal metrics in individuals with treatment-resistant depression (TRD) vs. healthy volunteers, finding that ketamine increases certain sleep-related brain activities but does not significantly mediate its ant…
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TLDR: Esketamine nasal spray, combined with standard antidepressant therapy, significantly improves remission rates and reduces time to remission in adults with major depressive disorder (MDD) and acute suicidality compared to standard care alone. Highlights:…
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Depression is highly prevalent in older adults and those with cardiovascular disease. Selective serotonin reuptake inhibitors (SSRIs) are generally safe first-line treatments, but many wonder if they’re safe for those with cardiovascular disease. Key Facts: Th…
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Researchers uncover a surprising molecular mechanism that explains ketamine’s exceptionally long-lasting antidepressant effects. Key Facts: Ketamine’s antidepressant effects last for days after its concentration drops to low, ineffective levels only an hour af…
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Major depressive disorder (MDD) is a global health crisis affecting over 300 million people. While available antidepressants help some patients, treatment is far from satisfactory for many. Exciting research into rapid-acting agents like ketamine and psilocybi…
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Big picture: Psychoplastogens are a groundbreaking new class of psychoactive compounds that rapidly induce structural and functional changes in the brain, allowing pathological neural circuits to be rewired for therapeutic benefit. Key facts about psychoplasto…
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