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The NLRP3 inflammasome is increasingly being recognized as a mediator between inflammation and depression. Targeting this molecular complex shows promise for developing new antidepressant therapies. Key Facts: The NLRP3 inflammasome is made up of NLRP3, ASC, a…
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Researchers conducted a comprehensive analysis comparing 20 antidepressants to identify the most effective options for preventing relapse in patients with major depressive disorder (MDD). Their findings suggest desvenlafaxine, paroxetine, venlafaxine and vorti…
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New research reveals that increased inflammation, indicated by higher levels of a protein called VCAM-1, is associated with decreased gray matter and altered brain connectivity in patients with major depressive disorder (MDD). These brain changes also correlat…
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A recent longitudinal study provides new insight into the association between intelligence in adolescence and mental health outcomes in middle age. The research indicates that higher intelligence in youth is linked to a lower risk of some common mental health…
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Major depressive disorder (MDD) is one of the most prevalent mental health conditions worldwide, yet its complex neurobiological underpinnings remain poorly understood. Emerging research implicates disturbances in neuronal apoptosis and neuroplasticity in the…
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Major depressive disorder (MDD) is a highly prevalent and debilitating condition. Novel treatment approaches are needed, especially for individuals with treatment-resistant depression. This study investigated the effects of adjunctive minocycline on immune-inf…
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Major depressive disorder (MDD) is a highly prevalent mental illness and leading cause of disability worldwide. While treatments exist, they are far from optimal and up to 30% of patients fail to respond. There is an urgent need to identify factors that may en…
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Vagus nerve stimulation (VNS) is an emerging form of brain stimulation showing promise for treating depression. Though still considered experimental, VNS has a long history dating back over 100 years. Recent advances are unlocking its potential as a new tool f…
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Suicide is a major public health problem, with over 700,000 people dying by suicide every year globally. Identifying factors that may indicate risk for suicidal thoughts and behaviors is an important area of research, as this could aid prevention and intervent…
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Researchers have discovered that changes in a region deep in the brain called the brainstem may contribute to recurring major depressive disorder (MDD). Key findings include: Patients with first-episode and recurrent depression showed volume decreases in brain…
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