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TL;DR: A 2026 review in Journal of Neuroinflammation proposed that Alzheimer microglial dysfunction can be understood as checkpoint collapse, where failed regulatory controls feed three interacting lipid, iron/ferroptosis, and inflammation/complement axes. Key…
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TL;DR: A 2026 review in Purinergic Signalling argues that ATP-gated P2X receptors, especially P2X7 and P2X4, may connect stress-related neuroinflammation with depression and bipolar-disorder biology. Key Findings P2X7 focus: The review describes P2X7 receptor…
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TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatme…
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