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TL;DR: A 2026 narrative review in International Journal of General Medicine argued that apathy in Alzheimer’s disease is tied to damage across motivation circuits, including the anterior cingulate cortex, orbitofrontal cortex, striatum, locus coeruleus, and la…
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TL;DR: A 2026 study in eLife found that prior cocaine self-administration disrupted how rat orbitofrontal cortex (OFC), a frontal brain region involved in task structure and flexible behavior, encoded hidden states in an odor-sequence task. Key Findings 3,881…
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TL;DR: A 2026 mouse study in Communications Biology found that activating parvalbumin (PV) interneurons, inhibitory nerve cells in the orbitofrontal cortex, reduced default mode network connectivity and decreased normal social approach and sniffing behavior. K…
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TL;DR: A 2026 randomized study in Psychological Medicine found that right orbitofrontal cortex repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain-stimulation method, improved visuospatial memory on the Brief Visuospatial Memory Test-Revis…
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A new brain imaging study reveals deficits in key networks involved in social functioning among individuals with schizophrenia. The findings shed light on the underlying neural mechanisms that may contribute to impaired social skills in this psychiatric disord…
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Obsessive-compulsive disorder (OCD) is a challenging psychiatric illness affecting 2% of the population. While some patients respond to therapy and medications, others continue to suffer from severe, treatment-resistant symptoms. Exciting new research shows th…
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