Connectivity-Guided iTBS Improved Inpatient Treatment-Resistant Depression Scores

Connectivity-Guided iTBS Improved Inpatient Treatment-Resistant Depression Scores

TL;DR: A 2026 randomized trial posted to medRxiv found that connectivity-guided accelerated intermittent theta-burst stimulation added to inpatient care improved treatment-resistant depression scores more than sham stimulation over 2 weeks. Key Findings 57 randomized patients: Hospitalized adults with unipolar treatment-resistant depression were assigned to active or sham stimulation. 30 iTBS sessions: Active treatment delivered 3 …

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Continuous Theta Burst Stimulation (cTBS) Ineffective for Depression? (New Meta-Analysis Reports No Benefit)

A new meta-analysis found that continuous theta burst stimulation (cTBS), a novel form of brain stimulation therapy, does not appear to be more effective than sham (placebo) stimulation for treating symptoms of major depression. Key Facts: cTBS is a type of repetitive transcranial magnetic brain stimulation that aims to modulate activity in certain brain regions …

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