Locus Coeruleus Axon Loss May Explain Alzheimer’s Smell Loss

Early Locus Coeruleus Axon Loss May Explain Smell Loss in Alzheimer’s

Early Locus Coeruleus Axon Loss May Explain Smell Loss in Alzheimer’s TL;DR: Alzheimer’s-model mice lost noradrenergic locus coeruleus axons in the olfactory bulb before major plaque buildup, took 60% longer to find buried food, and improved when microglial phagocytosis was reduced. Key Findings 3-month axon loss before heavy plaque load: AppNL-G-F mice showed a selective …

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