Locus Coeruleus Axon Loss May Explain Alzheimer’s Smell Loss
TL;DR: A 2025 mouse study in Nature Communications found early locus coeruleus axon loss in the olfactory bulb before heavy plaque buildup, offering a mechanism for Alzheimer’s-related smell loss. Key Findings TSPO knockout rescued smell: Cutting microglial phagocytosis preserved locus coeruleus axons and restored buried-food performance toward wild-type levels — the strongest causal piece. 60% …
