Depression is one of the most common mental health issues, affecting over 320 million people globally. Research shows that exercise may be an effective treatment option for many battling this disabling condition. Key Facts: Exercise has comparable antidepressant effects to medications and psychotherapy in clinical trials. Both aerobic and resistance training reduce depressive symptoms, with …
Researchers have discovered that several commonly prescribed antidepressants can promote antibiotic resistance and persistence in E. coli bacteria. This concerning finding implicates yet another widely used class of pharmaceuticals in exacerbating the global antibiotic resistance crisis. Key Facts: Antidepressants including sertraline and duloxetine were found to significantly increase E. coli’s resistance to multiple antibiotics like …
Researchers conducted a comprehensive analysis comparing 20 antidepressants to identify the most effective options for preventing relapse in patients with major depressive disorder (MDD). Their findings suggest desvenlafaxine, paroxetine, venlafaxine and vortioxetine balance efficacy and tolerability best for maintenance treatment. Key Facts: The analysis included 34 high-quality clinical trials with over 9,300 patients total. All …
Antidepressant medications like bupropion (Zyban) show potential to help people quit smoking long-term. However, the evidence is complex with both benefits and risks to consider carefully. Key facts: The antidepressant bupropion (brand name Zyban) aids quitting smoking versus no medication. Almost 50% more people successfully quit long-term with bupropion. However, bupropion also increases risks of …
Cognitive enhancement techniques hold great promise for boosting our mental abilities, but they may also come with hidden costs according to new research. Key Facts: Cognitive enhancement aims to improve mental functioning in healthy people through methods like brain stimulation, smart drugs, and cognitive training. While benefits have been the main focus, researchers argue that …
Estradiol enhances memory and other aspects of cognition in animals and humans, but translating the research into effective hormone replacement therapies (HRTs) has faced challenges. Recent developments indicate multiple mechanisms, along with some key facts: Estradiol enhances memory consolidation via genomic and rapid signaling cascades acting minutes-to-hours after learning. Synaptic plasticity and spine remodeling appear …
Researchers explore various drug compounds and their potential to enhance human cognition, including attention, learning, and higher-order thinking. While some progress has been made, many questions remain. Key Facts: Several drug compounds show potential to mildly enhance some cognitive functions like attention, learning, and memory. These include stimulants, wakefulness agents, and compounds that affect memory …
Major depressive disorder (MDD) is a global health crisis affecting over 300 million people. While available antidepressants help some patients, treatment is far from satisfactory for many. Exciting research into rapid-acting agents like ketamine and psilocybin combined with exploration of novel drug targets finally offers real hope for transformational change in how depression is treated. …
Antidepressants could potentially be repurposed as anticancer agents based on emerging evidence showing they can modulate autophagy—a process cancer cells rely on for growth and survival. Key Facts: Many antidepressants like SSRIs and TCAs have demonstrated anticancer effects in lab studies. Their mechanisms involve regulating autophagy, which plays a complex role in cancer development. Specific …
New research finds that regular running is just as effective as antidepressants for treating depression and anxiety, and leads to better physical health outcomes. Key Facts: In a study of 141 patients, running therapy and antidepressant medication had comparable effects on rates of remission (no longer meeting diagnostic criteria) from depression/anxiety disorders. However, running led …
